低分子肝素预防遗传性血栓形成女性妊娠丢失的荟萃分析。
A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia.
机构信息
The Ottawa Blood Disease Centre, Division of Hematology and Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada;
The Ottawa Blood Disease Centre, Division of Hematology and Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada;
出版信息
Blood. 2016 Mar 31;127(13):1650-5. doi: 10.1182/blood-2015-12-626739. Epub 2016 Feb 2.
We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19;P= .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.
我们对比较低分子量肝素（LMWH）与不使用 LMWH 治疗遗传性血栓形成倾向且既往有晚期（≥10 周）或复发性早期（<10 周）妊娠丢失的女性的随机对照试验进行了荟萃分析。8 项试验和 483 名患者符合我们的纳入标准。与不使用 LMWH 相比，使用 LMWH 并没有显著提高活产率（相对风险，0.81；95%置信区间，0.55-1.19；P=.28），这表明 LMWH 对预防遗传性血栓形成倾向女性的复发性妊娠丢失没有益处。
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