Bahari F, Emadi-Baygi M, Nikpour P
Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences; Applied Physiology Research Center, Isfahan University of Medical Sciences; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Indian J Cancer. 2015 Jan-Mar;52(1):22-5. doi: 10.4103/0019-509X.175605.
This study aimed to evaluate the expression of miR-17-92 host gene (MIR17HG), in gastric cancer and paired normal adjacent tissues for the 1st time.
Using quantitative real-time-polymerase chain reaction, the MIR17HG expression was assessed in 30 paired tumoral and nontumoral gastric tissue samples.
Our results showed that this transcript was significantly underexpressed in gastric tumors compared with normal ones. Furthermore, there was an association between the expression levels of MIR17HG and gastric cancer grades and stages. Moreover, the expression level of MIR17HG was conversely associated with the size of tumoral specimens in early stages (stages I and II). We also observed an association between the presence of metastasis and lower expression of MIR17HG.
Our results suggest that MIR17HG gene expression is dysregulated in gastric cancer in which it may indicate a tumor suppressive function of this miRNA cluster host gene in gastric cancer.
本研究旨在首次评估miR-17-92宿主基因（MIR17HG）在胃癌组织及配对的正常相邻组织中的表达情况。
采用定量实时聚合酶链反应，对30对肿瘤性和非肿瘤性胃组织样本中的MIR17HG表达进行评估。
我们的结果显示，与正常组织相比，该转录本在胃肿瘤组织中显著低表达。此外，MIR17HG的表达水平与胃癌的分级和分期之间存在关联。而且，在早期阶段（I期和II期），MIR17HG的表达水平与肿瘤标本大小呈负相关。我们还观察到转移的存在与MIR17HG的低表达之间存在关联。
我们的结果表明，MIR17HG基因表达在胃癌中失调，这可能表明该miRNA簇宿主基因在胃癌中具有肿瘤抑制功能。
