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非编码RNA在癌症转移中的坏死性凋亡、炎性程序性坏死及铁死亡中的作用

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis.

作者信息

Liu Yan, Chen Qiuyun, Zhu Yanan, Wang Tiying, Ye Lijuan, Han Lei, Yao Zhihong, Yang Zuozhang

机构信息

Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Cancer Hospital of Yunnan Province), Kunming, Yunnan, China.

Department of Pathology, The Third Affiliated Hospital of Kunming Medical University (Cancer Hospital of Yunnan Province), Kunming, Yunnan, China.

出版信息

Cell Death Discov. 2021 Aug 11;7(1):210. doi: 10.1038/s41420-021-00596-9.

Abstract

Distant metastasis is the main cause of death for cancer patients. Recently, the newly discovered programmed cell death includes necroptosis, pyroptosis, and ferroptosis, which possesses an important role in the process of tumor metastasis. At the same time, it is widely reported that non-coding RNA precisely regulates programmed death and tumor metastasis. In the present review, we summarize the function and role of necroptosis, pyrolysis, and ferroptosis involving in cancer metastasis, as well as the regulatory factors, including non-coding RNAs, of necroptosis, pyroptosis, and ferroptosis in the process of tumor metastasis.

摘要

远处转移是癌症患者死亡的主要原因。最近,新发现的程序性细胞死亡包括坏死性凋亡、炎性小体介导的细胞焦亡和铁死亡,它们在肿瘤转移过程中具有重要作用。同时,有广泛报道称非编码RNA精确调控程序性死亡和肿瘤转移。在本综述中,我们总结了坏死性凋亡、细胞焦亡和铁死亡在癌症转移中的功能和作用,以及肿瘤转移过程中坏死性凋亡、细胞焦亡和铁死亡的调节因子,包括非编码RNA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b2/8358062/ef15c81ffcec/41420_2021_596_Fig1_HTML.jpg

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