Holness D L, Taraschuk I G, Nethercott J R
Department of Occupational and Environmental Health, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Arch Environ Health. 1989 Sep-Oct;44(5):291-7. doi: 10.1080/00039896.1989.9935896.
Copper refinery workers exposed to selenium were studied before, during, and after a shutdown period. Urine selenium levels were 83 +/- 30 mumol/mol creatinine and 69 +/- 27 mumol/mol creatinine when measured on two occasions during exposure compared with 56 +/- 17 mumol/mol creatinine when the workers had been free of exposure for 10 wk during a shutdown. The refinery workers reported more nose and eye irritation, indigestion, stomach pain, and fatigue than controls. "Garlic-like" breath odor was reported to be personally and socially offensive by many of the workers. Reporting of symptoms, pulmonary function indices, and laboratory test results did not change with exposure except for hemoglobin level, which rose during the shutdown. Hemoglobin levels were found to be inversely correlated with the urine selenium level, and there was a positive correlation noted for the interactive effect of urine selenium and urine arsenic levels on hemoglobin.
对接触硒的铜冶炼厂工人在停工期间之前、期间和之后进行了研究。在接触期间两次测量时，尿硒水平分别为83±30μmol/mol肌酐和69±27μmol/mol肌酐，而在停工期间工人有10周未接触硒时，尿硒水平为56±17μmol/mol肌酐。与对照组相比，冶炼厂工人报告的鼻眼刺激、消化不良、胃痛和疲劳症状更多。许多工人报告说，“大蒜样”口气在个人和社交方面都令人反感。除血红蛋白水平在停工期间上升外，症状报告、肺功能指标和实验室检查结果并未随接触情况而改变。发现血红蛋白水平与尿硒水平呈负相关，并且尿硒和尿砷水平对血红蛋白的交互作用呈正相关。
