活动性韦格纳肉芽肿与抗细胞质抗体之间的关联。

Association between active Wegener's granulomatosis and anticytoplasmic antibodies.

作者信息

Tervaert J W, van der Woude F J, Fauci A S, Ambrus J L, Velosa J, Keane W F, Meijer S, van der Giessen M, van der Hem G K, The T H

机构信息

Department of Internal Medicine, University Hospital, Groningen, the Netherlands.

出版信息

Arch Intern Med. 1989 Nov;149(11):2461-5. doi: 10.1001/archinte.149.11.2461.

DOI:10.1001/archinte.149.11.2461

PMID:2684074

Abstract

Autoantibodies reacting with the cytoplasm of granulocytes and monocytes (anticytoplasmic antibodies [ACPAs]) were found in 42 of 45 patients with active Wegener's granulomatosis (WG) (sensitivity, 93%). Specificity was tested in selected groups of patients with closely related diseases. Of 58 patients without a diagnosis of WG, 2 had ACPAs (specificity, 97%). The significance of ACPA titration for assessing or predicting disease activity was evaluated in a 16-month prospective study of 35 patients with WG. Seventeen relapses were observed and all were preceded by a significant rise of the ACPA titer. Anticytoplasmic antibodies are a specific and sensitive marker for active WG; a rising titer is a sensitive marker for the development of a relapse.

摘要

在45例活动期韦格纳肉芽肿（WG）患者中，有42例检测到与粒细胞和单核细胞胞质发生反应的自身抗体（抗胞质抗体[ACPA]）（敏感性为93%）。在患有密切相关疾病的特定患者组中测试了其特异性。在58例未诊断为WG的患者中，有2例存在ACPA（特异性为97%）。在一项对35例WG患者进行的为期16个月的前瞻性研究中，评估了ACPA滴度对评估或预测疾病活动的意义。观察到17次复发，所有复发之前ACPA滴度均显著升高。抗胞质抗体是活动期WG的一种特异性和敏感性标志物；滴度升高是复发发生的敏感标志物。