Vandekerckhove Thomas, Temmerman Linda, Calle Paul, Dutré Marieke
Universiteit Gent, faculteit Geneeskunde en Gezondheidswetenschappen, Gent, België.
Ned Tijdschr Geneeskd. 2016;160:A9740.
Acute generalised exanthematous pustulosis (AGEP) is a rare and self-limiting pustular cutaneous reaction to a drug or infection.
A 62-year-old male presented to the Emergency Department with fever, erythema and pustules on both thighs. The initial blood analysis showed increased inflammatory parameters. The patient was admitted to the Dermatology Department with suspected AGEP. All medication was stopped. The diagnosis was confirmed histologically. During hospitalisation, the cutaneous reaction spread over 30% of the skin surface. Seven days after onset, the skin disorder regressed and the patient was discharged after 16 days. Use of amoxicillin/clavulanic acid was very likely the triggering factor for the development of AGEP.
AGEP, although self-limiting, can have a fulminant course, requiring admission to a burns centre. It is imperative that rechallenge with the triggering drug is avoided.
急性泛发性脓疱性皮病（AGEP）是一种罕见的、对药物或感染产生的自限性脓疱性皮肤反应。
一名62岁男性因双侧大腿发热、红斑和脓疱就诊于急诊科。初始血液分析显示炎症参数升高。该患者因疑似AGEP入住皮肤科。停用所有药物。组织学检查确诊。住院期间，皮肤反应蔓延至皮肤表面的30%。发病7天后，皮肤病变消退，患者于16天后出院。阿莫西林/克拉维酸很可能是AGEP发生的触发因素。
AGEP虽然是自限性的，但病程可能迅猛，需要入住烧伤中心。必须避免再次使用触发药物。
