High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.
作者信息
Allensworth Jordan J, Troob Scott H, Lanciault Christian, Andersen Peter E
机构信息
Department of Otolaryngology - Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon.
Department of Pathology, Oregon Health and Science University, Portland, Oregon.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E2425-7. doi: 10.1002/hed.24378. Epub 2016 Feb 3.
BACKGROUND
Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy.
METHODS AND RESULTS
We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness and was found to have a left-sided nasopharyngeal mass with intracranial extension on CT scan. A biopsy of the mass revealed nasopharyngeal angiofibroma. The patient opted for MRI surveillance, which revealed interval growth 3 years later. Decompression surgery revealed only angiofibroma, but resection 9 months later demonstrated high-grade sarcoma and concomitant angiofibroma. The patient had residual disease which progressed through chemoradiation, and is now pursuing clinical trial enrollment.
CONCLUSION
Malignant transformation of nasopharyngeal angiofibroma is extremely rare. As highlighted by this report, high-grade undifferentiated lesions may arise in tumors without previous radiation. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2425-E2427, 2016.
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