De Sanctis Vincenzo, Soliman Ashraf, Bernasconi Sergio, Bianchin Luigi, Bona Gianni, Bozzola Mauro, Buzi Fabio, De Sanctis Carlo, Tonini Giorgio, Rigon Franco, Perissinotto Egle
Pediatr Endocrinol Rev. 2015 Dec;13(2):512-20.
Dysmenorrhea is commonly categorized into two types; primary and secondary. Primary dysmenorrhea (PD) is the focus of this review. PD is defined as painful menses with cramping sensation in the lower abdomen that is often accompanied by other symptoms, such as sweating, headache, nausea, vomiting, diarrhea, and tremulousness. All these symptoms occur just before or during the menses in women with normal pelvic anatomy. In adolescents the prevalence of PD varies between 16% and 93%, with severe pain perceived in 2% to 29% of the studied girls. Several studies suggest that severe menstrual pain is associated with absenteeism from school or work and limitation of other daily activities. One-third to one-half of females with PD are missing school or work at least once per cycle, and more frequently in 5% to 14% of them. The wide variation in the prevalence rates may be attributed to the use of selected groups of subjects. Many risk factors are associated with increased severity of dysmenorrhea including earlier age at menarche, long menstrual periods, heavy menstrual flow, smoking and positive family history. Young women using oral contraceptive pills (OCP) report less severe dysmenorrhea. The considerably high prevalence of dysmenorrhea among adolescents verified that this condition is a significant public health problem that requires great attention. SUMMARY OF MAIN RESULTS: Many methodological problems are encountered during quantifying and grading severity of pain related to dysmenorrhea. Quantifying and assessment tools depend on women's self-reporting with potential bias. There is a scarcity of longitudinal studies on the natural history of dysmenorrhea as well as the possible effects of many modifiable risk factors. In addition, the duration of follow-up in the available studies is relatively short. Therefore, several aspects are still open for research. Medical treatment for dysmenorrhea includes anti-inflammatory drugs (NSAIDs), OCP or surgical intervention. The efficacy of conventional treatments using NSAIDs and OCP is high. However, failure rate may reach up to 20% to 25%, besides the occurrence of drug-associated adverse effects. Only 6% of adolescents receive medical advice to treat dysmenorrhea while 70% practice self-management. Unfortunately, some girls even abuse these medications (non-therapeutic high doses) for quick pain relief. The persistence of dysmenorrhea despite the use of OCP and/or NSAIDs drugs is a strong indicator of an organic pelvic disease. This condition mandates an appropriate referral to a gynecologist with proper laparoscopic diagnosis of endometriosis and/or other pelvic diseases.
Dysmenorrhea is an important health problem for adolescents, school and occupational as well as practitioners that adversely affects the daily activities and quality of life for adolescent women. The accurate prevalence of dysmenorrhea is difficult to establish due to the variety of diagnostic criteria and the subjective nature of the symptoms. In adolescents, moderate to severe dysmenorrhea that affects lifestyle and does not respond to medical treatment requires professional attention and proper diagnosis of possible underlying pelvic disease. Therefore, adolescent care providers should be more knowledgeable and actively involved in the care of dysmenorrhea.
痛经通常分为两种类型,即原发性和继发性。本综述聚焦于原发性痛经(PD)。原发性痛经被定义为月经期间下腹部出现痉挛性疼痛,并常伴有其他症状,如出汗、头痛、恶心、呕吐、腹泻和颤抖。所有这些症状均出现在盆腔解剖结构正常的女性月经前或月经期间。在青少年中,原发性痛经的患病率在16%至93%之间,2%至29%的被研究女孩有严重疼痛。多项研究表明,严重的经期疼痛与缺课或旷工以及其他日常活动受限有关。三分之一至二分之一的原发性痛经女性每个月经周期至少缺课或旷工一次,其中5%至14%的人更为频繁。患病率的广泛差异可能归因于所选取的研究对象群体。许多风险因素与痛经严重程度增加有关,包括初潮年龄较早、经期长、经量多、吸烟以及家族史阳性。使用口服避孕药(OCP)的年轻女性报告痛经较轻。青少年中痛经患病率相当高,证实了这一情况是一个重大的公共卫生问题,需要高度关注。
在量化和分级与痛经相关的疼痛严重程度时会遇到许多方法学问题。量化和评估工具依赖于女性的自我报告,可能存在偏差。关于痛经自然史以及许多可改变风险因素可能影响的纵向研究较少。此外,现有研究的随访时间相对较短。因此,仍有几个方面有待研究。痛经的药物治疗包括抗炎药(非甾体抗炎药)、口服避孕药或手术干预。使用非甾体抗炎药和口服避孕药的传统治疗效果较高。然而,除了出现药物相关不良反应外,失败率可能高达20%至25%。只有6%的青少年接受治疗痛经的医学建议,而70%进行自我管理。不幸的是,一些女孩甚至滥用这些药物(非治疗性高剂量)以快速缓解疼痛。尽管使用了口服避孕药和/或非甾体抗炎药但痛经仍持续,这强烈提示存在器质性盆腔疾病。这种情况需要适当转诊至妇科医生,通过腹腔镜正确诊断子宫内膜异位症和/或其他盆腔疾病。
痛经对青少年、学校、职业以及从业者来说都是一个重要的健康问题,会对青少年女性的日常活动和生活质量产生不利影响。由于诊断标准多样以及症状的主观性,痛经的准确患病率难以确定。在青少年中,影响生活方式且对药物治疗无反应的中度至重度痛经需要专业关注以及对可能存在的潜在盆腔疾病进行正确诊断。因此,青少年护理提供者应具备更多知识,并积极参与痛经的护理。