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体重指数对全髋关节置换术后并发症及再次手术的影响。

Effect of Body Mass Index on Complications and Reoperations After Total Hip Arthroplasty.

作者信息

Wagner Eric R, Kamath Atul F, Fruth Kristin M, Harmsen William S, Berry Daniel J

机构信息

Departments of Orthopedic Surgery (E.R.W., A.F.K., and D.J.B.) and Biostatistics and Health Sciences Research (K.F. and W.S.H.), Mayo Clinic, Rochester, Minnesota

出版信息

J Bone Joint Surg Am. 2016 Feb 3;98(3):169-79. doi: 10.2106/JBJS.O.00430.

Abstract

BACKGROUND

High body mass index (BMI) is associated with increased rates of complications after total hip arthroplasty. Studies to date have evaluated risk mainly as a dichotomous variable according to BMI thresholds. The purpose of this paper was to characterize the risk of complications and implant survival according to BMI as a continuous variable.

METHODS

Using prospectively collected data from our institutional total joint registry, we analyzed 21,361 consecutive hips (17,774 patients) treated with primary total hip arthroplasty between 1985 and 2012 at a single institution. The average BMI at the time of surgery was 28.7 kg/m(2) (range, 15 to 69 kg/m(2)). Estimates of revision surgery and common complications associated with BMI were analyzed using the Kaplan-Meier method of assessing survivorship, with associations of outcomes assessed using a Cox model.

RESULTS

Utilizing smoothing spline parameterization, we found that reoperation (p < 0.001) and implant revision or removal rates (p = 0.002) increased with increasing BMI. Increasing BMI was associated with increased rates of early hip dislocation (p = 0.02), wound infection, and, most strikingly, deep periprosthetic infection (a hazard ratio of 1.09 per unit of BMI >25 kg/m(2); p < 0.001). However, we found no association between increasing BMI and any revision for mechanical failure of the implant or between increasing BMI and revision for aseptic implant loosening. There was an inverse correlation between increasing BMI and risk of revision for bearing wear.

CONCLUSIONS

The rates of reoperation, implant revision or removal, and common complications after total hip arthroplasty were strongly associated with BMI.

摘要

背景

高体重指数(BMI)与全髋关节置换术后并发症发生率增加相关。迄今为止的研究主要根据BMI阈值将风险评估为二分变量。本文的目的是将BMI作为连续变量来描述并发症风险和植入物生存率。

方法

利用我们机构全关节登记处前瞻性收集的数据,我们分析了1985年至2012年在单一机构接受初次全髋关节置换术的21361例连续髋关节(17774例患者)。手术时的平均BMI为28.7kg/m²(范围为15至69kg/m²)。使用Kaplan-Meier生存评估方法分析与BMI相关的翻修手术和常见并发症的估计值,并使用Cox模型评估结果的相关性。

结果

利用平滑样条参数化,我们发现再次手术率(p<0.001)和植入物翻修或取出率(p = 0.002)随BMI增加而升高。BMI增加与早期髋关节脱位率增加(p = 0.02)、伤口感染以及最显著的假体周围深部感染相关(BMI>25kg/m²时每单位的风险比为1.09;p<0.001)。然而,我们发现BMI增加与植入物机械故障的任何翻修之间或BMI增加与无菌性植入物松动的翻修之间均无关联。BMI增加与因轴承磨损导致的翻修风险呈负相关。

结论

全髋关节置换术后的再次手术率、植入物翻修或取出率以及常见并发症与BMI密切相关。

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