Institute of Neuropathology, University of Freiburg , D-79106 Freiburg, Germany.
BIOSS Centre for Biological Signalling Studies, University of Freiburg , D-79106 Freiburg, Germany.
ACS Chem Neurosci. 2016 Apr 20;7(4):428-34. doi: 10.1021/acschemneuro.5b00317. Epub 2016 Feb 4.
Microglia are the resident monocytic cells in the central nervous system (CNS), where they constitute the complex tissue structure together with a diverse set of cell-types, including neurons, glial cells, and vasculature. Different from other cells, microglia have distinct features, including not only their origin but functions in the CNS, and serve multiple roles within healthy and diseased CNS tissue. The present review highlights the latest advance in our understanding of the nature of microglia in the CNS, from their origin to both the physiological and pathological roles throughout their whole life.
小胶质细胞是中枢神经系统（CNS）中的常驻单核细胞，它们与神经元、神经胶质细胞和血管等多种细胞类型一起构成了复杂的组织结构。与其他细胞不同，小胶质细胞具有独特的特征，不仅包括其起源，还包括其在中枢神经系统中的功能，并在健康和患病的中枢神经系统组织中发挥多种作用。本综述强调了我们对中枢神经系统中小胶质细胞本质的最新理解，包括其起源以及整个生命周期中的生理和病理作用。
