Ho Yi-Te, Kao Tung-Wei, Peng Tao-Chun, Liaw Fang-Yih, Yang Hui-Fang, Sun Yu-Shan, Chang Yaw-Wen, Chen Wei-Liang
From the Division of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China (ROC), (YT-H, TW-K, TC-P, FY-L, HF-Y, YS-S, YW-C, WL-C); Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China (ROC), (TW-K, FY-L, YW-C, WL-C); Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei (FY-H, WL-C); and Graduate Institute of Clinical Medical, College of Medicine, National Taiwan University, Taipei, Taiwan (TW-K).
Medicine (Baltimore). 2016 Feb;95(5):e2656. doi: 10.1097/MD.0000000000002656.
Preserving physical and cognitive function becomes an important issue as people age. A growing number of studies have found that the correlation between body mass index (BMI) and cognitive function changes in different age groups. It is obvious that higher educational status is linked to higher cognitive function in terms of numerous risk factors that influence cognitive function. This study aimed to investigate the interplay between obesity and cognitive function categorized by different educational status.This study included 5021 participants aged 20 to 59 years who completed 3 neurocognitive function tests, including a simple reaction time test (SRTT), a symbol digit substitution test (SDST), and a serial digit learning test (SDLT) as reported in the National Health and Nutrition Examination Survey (NHANES) III database. The associations between neurocognitive function and BMI were analyzed using multivariate linear regression while controlling for confounders.After adjusting for pertinent covariates in mode 3, the β coefficients in the female participants with more than 12 years of education (interpreted as change of 3 neurocognitive function tests for each increment in BMI) comparing obesity groups to those with normal BMI were 16.2 (P < 0.001 for SRTT), 0.14 (P < 0.05 for SDST), and 0.9 (P < 0.05 for SDLT). Male participants with more than 12 years of education and female participants with fewer than 12 years of education demonstrated increased impairment as their BMI increased. However, this association was not significant after adjustments.Obese individuals had worse neurocognitive function than those of normal weight or overweight, especially in women with a high educational level.
随着人们年龄的增长，保持身体和认知功能成为一个重要问题。越来越多的研究发现，体重指数（BMI）与认知功能之间的相关性在不同年龄组中有所变化。显然，就影响认知功能的众多风险因素而言，较高的教育水平与较高的认知功能相关。本研究旨在探讨肥胖与不同教育水平分类下的认知功能之间的相互作用。本研究纳入了5021名年龄在20至59岁之间的参与者，他们完成了3项神经认知功能测试，包括国家健康和营养检查调查（NHANES）III数据库中报告的简单反应时间测试（SRTT）、符号数字替代测试（SDST）和系列数字学习测试（SDLT）。在控制混杂因素的情况下，使用多元线性回归分析神经认知功能与BMI之间的关联。在模式3中调整相关协变量后，将肥胖组与正常BMI组进行比较，受教育年限超过12年的女性参与者中，（解释为BMI每增加一个单位，3项神经认知功能测试的变化）SRTT的β系数为16.2（P<0.001），SDST的β系数为0.14（P<0.05），SDLT的β系数为0.9（P<0.05）。受教育年限超过12年的男性参与者和受教育年限少于12年的女性参与者随着BMI的增加，损伤增加。然而，调整后这种关联并不显著。肥胖个体的神经认知功能比正常体重或超重个体更差，尤其是在教育水平较高的女性中。
