肥胖与认知功能的纵向研究：来自巴尔的摩老龄化纵向研究的结果。
Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging.
机构信息
Department of Psychology, Kent State University, Kent, Ohio 44242, USA.
出版信息
Neuroepidemiology. 2010;34(4):222-9. doi: 10.1159/000297742. Epub 2010 Mar 18.
Abstract
BACKGROUND
Obesity indices (i.e. BMI, waist-to-hip ratio) show differential relationships to other health outcomes, though their association to neurocognitive outcome is unclear.
METHODS
We examined whether central obesity would be more closely associated with cognitive function in 1,703 participants from the Baltimore Longitudinal Study of Aging.
RESULTS
Longitudinal mixed-effects regression models showed multiple obesity indices were associated with poorer performance in a variety of cognitive domains, including global screening measures, memory, and verbal fluency tasks. Obesity was associated with better performance on tests of attention and visuospatial ability. An obesity index by age interaction emerged in multiple domains, including memory and attention/executive function.
CONCLUSION
Obesity indices showed similar associations to cognitive function, and further work is needed to clarify the physiological mechanisms that link obesity to poor neurocognitive outcome.
摘要
背景
肥胖指数（即 BMI、腰臀比）与其他健康结果的关系不同，尽管它们与神经认知结果的关联尚不清楚。
方法
我们研究了在巴尔的摩老龄化纵向研究的 1703 名参与者中，中心性肥胖是否与认知功能更为密切相关。
结果
纵向混合效应回归模型显示，多种肥胖指数与多种认知领域的表现较差相关，包括全球筛查测量、记忆和语言流畅性任务。肥胖与注意力和视空间能力测试的表现较好相关。在多个领域（包括记忆和注意力/执行功能）中出现了肥胖指数与年龄的交互作用。
结论
肥胖指数与认知功能具有相似的关联，需要进一步的研究来阐明肥胖与神经认知结果不良之间的生理机制。
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