肥胖与认知功能的纵向研究：来自巴尔的摩老龄化纵向研究的结果。
Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging.
机构信息
Department of Psychology, Kent State University, Kent, Ohio 44242, USA.
出版信息
Neuroepidemiology. 2010;34(4):222-9. doi: 10.1159/000297742. Epub 2010 Mar 18.
Abstract
BACKGROUND
Obesity indices (i.e. BMI, waist-to-hip ratio) show differential relationships to other health outcomes, though their association to neurocognitive outcome is unclear.
METHODS
We examined whether central obesity would be more closely associated with cognitive function in 1,703 participants from the Baltimore Longitudinal Study of Aging.
RESULTS
Longitudinal mixed-effects regression models showed multiple obesity indices were associated with poorer performance in a variety of cognitive domains, including global screening measures, memory, and verbal fluency tasks. Obesity was associated with better performance on tests of attention and visuospatial ability. An obesity index by age interaction emerged in multiple domains, including memory and attention/executive function.
CONCLUSION
Obesity indices showed similar associations to cognitive function, and further work is needed to clarify the physiological mechanisms that link obesity to poor neurocognitive outcome.
摘要
背景
肥胖指数（即 BMI、腰臀比）与其他健康结果的关系不同，尽管它们与神经认知结果的关联尚不清楚。
方法
我们研究了在巴尔的摩老龄化纵向研究的 1703 名参与者中，中心性肥胖是否与认知功能更为密切相关。
结果
纵向混合效应回归模型显示，多种肥胖指数与多种认知领域的表现较差相关，包括全球筛查测量、记忆和语言流畅性任务。肥胖与注意力和视空间能力测试的表现较好相关。在多个领域（包括记忆和注意力/执行功能）中出现了肥胖指数与年龄的交互作用。
结论
肥胖指数与认知功能具有相似的关联，需要进一步的研究来阐明肥胖与神经认知结果不良之间的生理机制。
相似文献
1
Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging.
Neuroepidemiology. 2010;34(4):222-9. doi: 10.1159/000297742. Epub 2010 Mar 18.
2
Renal function and long-term decline in cognitive function: the Baltimore Longitudinal Study of Aging.
Am J Nephrol. 2015;41(4-5):305-12. doi: 10.1159/000430922. Epub 2015 Jun 6.
3
Aging, obesity, and post-therapy cognitive recovery in breast cancer survivors.
Oncotarget. 2017 Feb 14;8(7):12364-12373. doi: 10.18632/oncotarget.12565.
4
Examining the Influence of Measures of Adiposity on Cognitive Function in Middle Age and Older African Americans.
Arch Clin Neuropsychol. 2016 Feb;31(1):23-8. doi: 10.1093/arclin/acv086. Epub 2015 Dec 17.
5
Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging.
Hypertension. 2008 Jan;51(1):99-104. doi: 10.1161/HYPERTENSIONAHA.107.093674. Epub 2007 Nov 19.
6
Blood pressure reactivity and cognitive function in the Baltimore Longitudinal Study of Aging.
Health Psychol. 2009 Sep;28(5):641-6. doi: 10.1037/a0015215.
7
Neuropsychological Functioning in Mid-life Treatment-Seeking Adults with Obesity: a Cross-sectional Study.
Obes Surg. 2018 Feb;28(2):532-540. doi: 10.1007/s11695-017-2894-0.
8
Body mass index and neurocognitive functioning across the adult lifespan.
Neuropsychology. 2013 Mar;27(2):141-51. doi: 10.1037/a0031988.
9
Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.
J Am Geriatr Soc. 2015 Sep;63(9):1837-44. doi: 10.1111/jgs.13609. Epub 2015 Aug 27.
10
The Association between Physical Frailty and Cognitive Performance in Older Adults Aged 60 to 96 Years: Data from the "Good Aging in Skåne" (GÅS) Swedish Population Study.
Ann Geriatr Med Res. 2024 Sep;28(3):330-341. doi: 10.4235/agmr.24.0055. Epub 2024 May 17.
引用本文的文献
1
Maintaining long-term frequent tea consumption could reduce the risk of cognitive decline: results from a 10-year longitudinal study.
Front Nutr. 2025 Jun 18;12:1569850. doi: 10.3389/fnut.2025.1569850. eCollection 2025.
2
Body mass index-specific metabolic profiles in schizophrenia: implications for cognitive dysfunction and psychopathology.
J Neural Transm (Vienna). 2025 May 24. doi: 10.1007/s00702-025-02951-x.
3
Predicting Cognitive Outcome Through Nutrition and Health Markers Using Supervised Machine Learning.
J Nutr. 2025 Jul;155(7):2144-2153. doi: 10.1016/j.tjnut.2025.05.003. Epub 2025 May 12.
4
Evaluation of the relationship between types of menopause and cognitive function.
Turk J Med Sci. 2024 Jul 24;54(6):1346-1354. doi: 10.55730/1300-0144.5918. eCollection 2024.
5
Body mass index, waist circumference, hip circumference, abdominal volume index, and cognitive function in older Chinese people: a nationwide study.
BMC Geriatr. 2024 Nov 8;24(1):925. doi: 10.1186/s12877-024-05521-0.
6
Sex differences in the association of overweight with cognitive performance in individuals with first-episode psychosis.
Schizophrenia (Heidelb). 2024 Oct 23;10(1):95. doi: 10.1038/s41537-024-00521-w.
7
Prospective Comparison of Mental Planning Ability in Sleeve Gastrectomy Patients and Non-operative Controls.
Obes Surg. 2024 Oct;34(10):3901-3904. doi: 10.1007/s11695-024-07440-w. Epub 2024 Sep 15.
8
The association between Weight-adjusted-Waist Index (WWI) and cognitive function in older adults: a cross-sectional NHANES 2011-2014 study.
BMC Public Health. 2024 Aug 8;24(1):2152. doi: 10.1186/s12889-024-19332-w.
9
The role of dynapenia and obesity on cognitive function in older adults.
Clin Nutr ESPEN. 2024 Oct;63:191-196. doi: 10.1016/j.clnesp.2024.06.039. Epub 2024 Jun 26.
10
Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta.
Mol Neurobiol. 2025 Jan;62(1):1079-1093. doi: 10.1007/s12035-024-04320-3. Epub 2024 Jul 3.
本文引用的文献
1
Evidence of executive dysfunction in extremely obese adolescents: a pilot study.
Surg Obes Relat Dis. 2009 Sep-Oct;5(5):547-52. doi: 10.1016/j.soard.2009.05.008. Epub 2009 Jun 23.
2
Serum leptin levels are associated with cognitive function in older adults.
Brain Res. 2008 Sep 16;1230:233-6. doi: 10.1016/j.brainres.2008.07.045. Epub 2008 Jul 21.
3
Overweight is associated with decreased cognitive functioning among school-age children and adolescents.
Obesity (Silver Spring). 2008 Aug;16(8):1809-15. doi: 10.1038/oby.2008.296. Epub 2008 Jun 12.
4
Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults.
J Geriatr Psychiatry Neurol. 2008 Sep;21(3):166-70. doi: 10.1177/0891988708316860. Epub 2008 May 23.
5
Abeta40 is associated with cognitive function, body fat and physical fitness in healthy older adults.
Nutr Neurosci. 2007 Oct-Dec;10(5-6):205-9. doi: 10.1080/10284150701676156.
6
Role of the lateral prefrontal cortex in executive behavioral control.
Physiol Rev. 2008 Jan;88(1):37-57. doi: 10.1152/physrev.00014.2007.
7
Body mass index and neuropsychological function in healthy children and adolescents.
Appetite. 2008 Mar-May;50(2-3):246-51. doi: 10.1016/j.appet.2007.07.008. Epub 2007 Aug 2.
8
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults.
Compr Psychiatry. 2007 Jan-Feb;48(1):57-61. doi: 10.1016/j.comppsych.2006.05.001. Epub 2006 Jun 30.
9
Concurrent and separate effects of body mass index and waist-to-hip ratio on 24-year mortality in the Population Study of Women in Gothenburg: evidence of age-dependency.
Eur J Epidemiol. 2006;21(11):789-94. doi: 10.1007/s10654-006-9074-1. Epub 2006 Nov 17.
10
Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications.
Interdiscip Top Gerontol. 2007;35:159-75. doi: 10.1159/000096561.
Zotero 插件