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c-Met和CREB1通过调节Akt/GSK-3β/Snail信号通路参与miR-433介导的膀胱癌上皮-间质转化抑制作用。

c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial-mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling.

作者信息

Xu X, Zhu Y, Liang Z, Li S, Xu X, Wang X, Wu J, Hu Z, Meng S, Liu B, Qin J, Xie L, Zheng X

机构信息

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Cell Death Dis. 2016 Feb 4;7(2):e2088. doi: 10.1038/cddis.2015.274.

DOI:10.1038/cddis.2015.274
PMID:26844702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4849142/
Abstract

Emerging evidence has suggested that microRNAs (miRNAs) have an important role in tumor development and progression by regulating diverse cellular pathways. Here we describe the function and regulation network of miR-433 in bladder cancer (BCa). miR-433 is frequently downregulated in BCa tissues compared with adjacent non-cancerous tissues. Epigenetic mechanisms may be involved in the regulation of miR-433 expression. Enforced expression of miR-433 significantly inhibits proliferation, colony formation, migration, and invasion in BCa cells. In addition, miR-433 inhibits the epithelial-mesenchymal transition (EMT) in BCa cells by regulating c-Met/Akt/GSK-3β/Snail signaling pathway. Both c-Met and CREB1 are downstream target genes of miR-433. CREB1 can also indirectly regulate c-Met/Akt/GSK-3β/Snail signaling via MITF. Furthermore, CREB1 expression is an independent prognostic factor for overall survival in patients with BCa. Finally, there appears to exist a reciprocal regulation between c-Met and miR-433/miR-409-3p. Taken together, this study reveals that miR-433-c-MET/CREB1-Akt/GSK-3β/Snail signaling is critical to EMT in BCa. Targeting the pathway described here may open up new prospects to restrict metastatic progression of BCa.

摘要

新出现的证据表明，微小RNA（miRNA）通过调节多种细胞途径在肿瘤发生和发展中发挥重要作用。在此，我们描述了miR - 433在膀胱癌（BCa）中的功能和调控网络。与相邻的非癌组织相比，miR - 433在BCa组织中经常下调。表观遗传机制可能参与miR - 433表达的调控。miR - 433的强制表达显著抑制BCa细胞的增殖、集落形成、迁移和侵袭。此外，miR - 433通过调节c - Met/Akt/GSK - 3β/Snail信号通路抑制BCa细胞中的上皮-间质转化（EMT）。c - Met和CREB1都是miR - 433的下游靶基因。CREB1还可通过MITF间接调节c - Met/Akt/GSK - 3β/Snail信号通路。此外，CREB1表达是BCa患者总生存的独立预后因素。最后，c - Met与miR - 433/miR - 409 - 3p之间似乎存在相互调节关系。综上所述，本研究揭示了miR - 433 - c - MET/CREB1 - Akt/GSK - 3β/Snail信号通路对BCa中的EMT至关重要。靶向此处描述的通路可能为限制BCa的转移进展开辟新的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/2b6508c72442/cddis2015274f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/b1230772b4e8/cddis2015274f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/009eb2272e73/cddis2015274f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/861939c53f83/cddis2015274f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/15b467e2bdea/cddis2015274f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/d0f80b1f3589/cddis2015274f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/9f06460930c0/cddis2015274f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/2b6508c72442/cddis2015274f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/b1230772b4e8/cddis2015274f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/009eb2272e73/cddis2015274f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/861939c53f83/cddis2015274f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/15b467e2bdea/cddis2015274f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/d0f80b1f3589/cddis2015274f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/9f06460930c0/cddis2015274f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4849142/2b6508c72442/cddis2015274f7.jpg

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本文引用的文献

1
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2
MicroRNA-576-3p inhibits proliferation in bladder cancer cells by targeting cyclin D1.微小RNA-576-3p通过靶向细胞周期蛋白D1抑制膀胱癌细胞的增殖。
Mol Cells. 2015;38(2):130-7. doi: 10.14348/molcells.2015.2146. Epub 2014 Dec 30.
3
High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression.
微小RNA在导致慢性肾脏病的肾纤维化中的作用
Biomedicines. 2023 Aug 23;11(9):2358. doi: 10.3390/biomedicines11092358.
4
CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation.CREB1 激活促进人乳头瘤病毒癌基因表达和宫颈癌细胞转化。
J Med Virol. 2023 Aug;95(8):e29025. doi: 10.1002/jmv.29025.
5
miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer.miRNAs：癌症的潜在生物标志物和治疗靶点。
Genes (Basel). 2023 Jun 29;14(7):1375. doi: 10.3390/genes14071375.
6
Tauroursodeoxycholic Acid Enhances Osteogenic Differentiation through EGFR/p-Akt/CREB1 Pathway in Mesenchymal Stem Cells.牛磺熊去氧胆酸通过 EGFR/p-Akt/CREB1 通路增强间充质干细胞的成骨分化。
Cells. 2023 May 24;12(11):1463. doi: 10.3390/cells12111463.
7
Targeting c-Met in the treatment of urologic neoplasms: Current status and challenges.靶向c-Met治疗泌尿系统肿瘤：现状与挑战
Front Oncol. 2023 Mar 7;13:1071030. doi: 10.3389/fonc.2023.1071030. eCollection 2023.
8
Non-coding RNA and autophagy: Finding novel ways to improve the diagnostic management of bladder cancer.非编码RNA与自噬：寻找改善膀胱癌诊断管理的新方法。
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9
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10
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高迁移率族蛋白盒1通过抑制转录因子CREB的激活和nWASP的表达来抑制癌细胞的运动和转移。
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4
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J Exp Clin Cancer Res. 2014 Sep 2;33(1):69. doi: 10.1186/s13046-014-0069-6.
5
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6
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Onco Targets Ther. 2014 May 29;7:873-9. doi: 10.2147/OTT.S63594. eCollection 2014.
7
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8
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9
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Expert Rev Anticancer Ther. 2014 Mar;14(3):289-95. doi: 10.1586/14737140.2014.868775. Epub 2014 Jan 8.
10
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Biochem Biophys Res Commun. 2013 Nov 29;441(4):976-81. doi: 10.1016/j.bbrc.2013.11.006. Epub 2013 Nov 9.