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心肌炎。

Myocarditis.

机构信息

From the Department of Pathology and Laboratory Medicine (G.F., H.L., Y.Q., D.Y., B.M.), Centre for Heart Lung Innovation (G.F., H.L., Y.Q., D.Y., B.M.), Centre of Excellence for Prevention of Organ Failure (PROOF Centre), and Institute for Heart + Lung Health, St. Paul's Hospital (B.M.), University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Circ Res. 2016 Feb 5;118(3):496-514. doi: 10.1161/CIRCRESAHA.115.306573.

Abstract

Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.

摘要

病毒性心肌炎仍然是患者一生中一种突出的感染性炎症性疾病。该疾病存在一些挑战,包括不同的临床表现模式、患者引起关注的时间点范围、诊断方法的多样性、临床病程谱,以及在不同患者环境中和面对不同病毒病原体时治疗方法的不确定性。在这篇综述中,我们检查了关于病毒性心脏病的现有知识,特别是提供了关于疾病机制的不断发展的认识的信息,以及研究人员努力识别和评估潜在治疗干预途径的信息。

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