Leschner Sara, Weiss Siegfried
Department of Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
Methods Mol Biol. 2016;1409:61-8. doi: 10.1007/978-1-4939-3515-4_6.
Non-invasive in vivo imaging represents a powerful tool to monitor cellular and molecular processes in the living animal. In the special case of bacteria-mediated cancer therapy using bioluminescent bacteria, it opens up the possibility to follow the course of the microorganisms into the tumor via the circulation. The mechanism by which bacteria elicit their anti-tumor potential is not completely understood. However, this knowledge is crucial to improve bacteria as an anti-cancer tool that can be introduced into the clinic. For the study of these aspects, in vivo imaging can be considered a key technology.
非侵入性体内成像技术是监测活体动物体内细胞和分子过程的有力工具。在使用生物发光细菌进行细菌介导的癌症治疗这种特殊情况下，它为追踪微生物通过循环进入肿瘤的过程提供了可能。细菌发挥其抗肿瘤潜力的机制尚未完全明确。然而，了解这一机制对于改进细菌作为一种可引入临床的抗癌工具至关重要。对于这些方面的研究，体内成像可被视为一项关键技术。
