Kolahian Saeed, Öz Hasan Halit, Zhou Benyuan, Griessinger Christoph M, Rieber Nikolaus, Hartl Dominik
Children's Hospital of the University of Tübingen, Pediatric Infectiology, Immunology & Cystic Fibrosis, Tübingen, Germany Dept of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Children's Hospital of the University of Tübingen, Pediatric Infectiology, Immunology & Cystic Fibrosis, Tübingen, Germany.
Eur Respir J. 2016 Mar;47(3):967-77. doi: 10.1183/13993003.01572-2015. Epub 2016 Feb 4.
Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterised by their potential to control T-cell responses and to dampen inflammation. While the role of MDSCs in cancer has been studied in depth, our understanding of their relevance for infectious and inflammatory disease conditions has just begun to evolve. Recent studies highlight an emerging and complex role for MDSCs in pulmonary diseases. In this review, we discuss the potential contribution of MDSCs as biomarkers and therapeutic targets in lung diseases, particularly lung cancer, tuberculosis, chronic obstructive pulmonary disease, asthma and cystic fibrosis.
髓源性抑制细胞（MDSCs）是一类固有免疫细胞，其特点是具有控制T细胞反应和减轻炎症的潜力。虽然MDSCs在癌症中的作用已得到深入研究，但我们对它们在感染性和炎症性疾病中的相关性的理解才刚刚开始发展。最近的研究突出了MDSCs在肺部疾病中一个新出现的复杂作用。在这篇综述中，我们讨论了MDSCs作为肺部疾病，特别是肺癌、肺结核、慢性阻塞性肺疾病、哮喘和囊性纤维化的生物标志物和治疗靶点的潜在作用。
