Upham John W, Xi Yang
School of Medicine, The University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Australia; Department of Respiratory Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia.
School of Medicine, The University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Australia.
Chest. 2017 Mar;151(3):668-673. doi: 10.1016/j.chest.2016.09.030. Epub 2016 Oct 8.
Dendritic cells (DCs) are potent antigen-presenting cells. Because of their particular ability to initiate and regulate cell mediated and humoral immune responses, there is considerable interest in the role that DCs play in the pathogenesis of various lung diseases, especially those in which there is an excessive immune response to specific antigens (as in asthma) or a deficient immune response (as in lung cancer). A number of DC subpopulations have been defined in the lungs, including myeloid or conventional DCs that initiate T-cell immunity and antibody production and plasmacytoid DCs that have an important role in antiviral immunity and immune tolerance. Although an extensive body of literature has documented the role that DCs play in experimental models of lung disease, this review will highlight recent advances in our understanding of DC function in human disease, including asthma, COPD, antimicrobial immunity, and lung cancer. The future is likely to see new approaches whereby antigens and small molecules are targeted to receptors on particular DC subpopulations in order to modify pulmonary immune responses.
树突状细胞（DCs）是强大的抗原呈递细胞。由于它们具有启动和调节细胞介导的及体液免疫反应的特殊能力，人们对DCs在各种肺部疾病发病机制中所起的作用极为关注，尤其是那些对特定抗原存在过度免疫反应（如哮喘）或免疫反应不足（如肺癌）的疾病。肺部已确定了多种DC亚群，包括启动T细胞免疫和抗体产生的髓样或传统DC以及在抗病毒免疫和免疫耐受中起重要作用的浆细胞样DC。尽管大量文献记载了DCs在肺部疾病实验模型中的作用，但本综述将重点介绍我们对DC在人类疾病（包括哮喘、慢性阻塞性肺疾病、抗微生物免疫和肺癌）中功能理解的最新进展。未来可能会出现新的方法，使抗原和小分子靶向特定DC亚群上的受体，以改变肺部免疫反应。
