Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan.
Mol Nutr Food Res. 2016 May;60(5):1110-7. doi: 10.1002/mnfr.201500736. Epub 2016 Mar 11.
We have previously demonstrated in mice that a maternal high fat diet during lactation enhances the susceptibility of offspring to obesity and fatty liver. A causative molecule, however, is yet to be identified. Therefore, we examined the role of cholesterol, the dietary intake of which increases with consumption of a high fat diet. Excessive cholesterol intake is involved in the development of fatty liver, which in turn becomes a risk factor for metabolic syndrome, which includes obesity, insulin resistance, and dyslipidemia. However, our knowledge of the influences on offspring of excessive maternal cholesterol intake alone during pregnancy and lactation is limited. We examined how excessive maternal cholesterol intake during lactation influences susceptibility of the offspring to metabolic syndrome in mice.
High cholesterol intake promoted triacylglycerol accumulation in the liver of offspring (p < 0.05), and elevated expression of molecules involved in hepatic lipoprotein influx was identified as the underlying mechanism.
These findings demonstrate that excessive maternal cholesterol intake during lactation enhances the susceptibility of the offspring to development of fatty liver.
我们之前在小鼠中证明，哺乳期高脂肪饮食会增加后代肥胖和脂肪肝的易感性。然而，目前尚未确定致病分子。因此，我们研究了胆固醇的作用，胆固醇的摄入量随着高脂肪饮食的摄入而增加。过量的胆固醇摄入与脂肪肝的发生有关，而脂肪肝反过来又成为代谢综合征的一个风险因素，包括肥胖、胰岛素抵抗和血脂异常。然而，我们对怀孕期间和哺乳期过量的母体胆固醇摄入对后代的影响知之甚少。我们研究了哺乳期过量的母体胆固醇摄入如何影响后代患代谢综合征的易感性。
高胆固醇摄入促进了后代肝脏中三酰甘油的积累（p < 0.05），并确定了涉及肝内脂蛋白流入的分子表达增加是其潜在机制。
这些发现表明，哺乳期过量的母体胆固醇摄入会增加后代发生脂肪肝的易感性。
