Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, São Paulo State University (Unesp), Botucatu, São Paulo State, Brazil.
Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil.
Oxid Med Cell Longev. 2021 Nov 24;2021:9073859. doi: 10.1155/2021/9073859. eCollection 2021.
Maternal exposure to the high-fat diet (HFD) during gestation or lactation can be harmful to both a mother and offspring. The aim of this systematic review was to identify and evaluate the studies with animal models (rodents) that were exposed to the high-fat diet during pregnancy and/or lactation period to investigate oxidative stress and lipid and liver enzyme profile of mothers and their offspring. The electronic search was performed in the PUBMED (Public/Publisher MEDLINE), EMBASE (Ovid), and Web of Science databases. Data from 77 studies were included for qualitative analysis, and of these, 13 studies were included for meta-analysis by using a random effects model. The pooled analysis revealed higher malondialdehyde levels in offspring of high-fat diet groups. Furthermore, the pooled analysis showed increased reactive oxygen species and lower superoxide dismutase and catalase in offspring of mothers exposed to high-fat diet during pregnancy and/or lactation. Despite significant heterogeneity, the systematic review shows oxidative stress in offspring induced by maternal HFD.
母体在妊娠或哺乳期暴露于高脂肪饮食（HFD）可能对母亲和后代都有害。本系统评价的目的是确定和评估动物模型（啮齿动物）的研究，这些研究在妊娠和/或哺乳期暴露于高脂肪饮食，以研究母体及其后代的氧化应激和脂质及肝酶谱。电子检索在 PUBMED（公共/出版商 MEDLINE）、EMBASE（Ovid）和 Web of Science 数据库中进行。对 77 项研究的数据进行了定性分析，其中 13 项研究采用随机效应模型进行了荟萃分析。汇总分析显示高脂肪饮食组后代的丙二醛水平升高。此外，汇总分析显示，在妊娠和/或哺乳期暴露于高脂肪饮食的母亲的后代中，活性氧增加，超氧化物歧化酶和过氧化氢酶降低。尽管存在显著的异质性，但系统评价显示母体 HFD 引起的后代氧化应激。
