Qayum Abdul, Arya Rakesh, Lynn Andrew M
Center for Biology and Bioinformatics, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Indira Gandhi National Forest Academy, Dehradun, India.
BMC Res Notes. 2016 Feb 4;9:67. doi: 10.1186/s13104-015-1827-z.
Considering the demand of antimalarial plants it has become essential to find and locate them for their optimal extraction. The work aims to find plants with antimalarial activities which were used by the local people; to raise the value of traditional knowledge system (TKS) prevalent in the study region; to compile characteristics of local plants used in malaria treatment (referred as antimalarial plants) and to have its spatial distribution analysis to establish a concept of geographical health.
Antimalarial plants are listed based on literature survey and field data collected during rainy season, from 85 respondents comprised of different ethnic groups. Ethno-medicinal utilities of plants was extracted; botanical name, family, local name, part used, folklore, geographical location and image of plants were recorded after cross validating with existing literatures. The interview was trifurcated in field, Vaidya/Hakims and house to house. Graphical analysis was done for major plants families, plant part used, response of people and patients and folklore. Mathematical analysis was done for interviewee's response, methods of plant identification and people's preferences of TKS through three plant indices.
Fifty-one plants belonging to 27 families were reported with its geographical attributes. It is found plant root (31.75 %) is used mostly for malaria treatment and administration mode is decoction (41.2 %) mainly. The study area has dominance of plants of family Fabaceae (7), Asteraceae (4), Acanthaceae (4) and Amaranthaceae (4). Most popular plants found are Adhatoda vasica, Cassia fistula and Swertia chirata while % usage of TKS is 82.0 % for malaria cure.
The research findings can be used by both scientific community and common rural people for bio-discovery of these natural resources sustainably. The former can extract the tables to obtain a suitable plant towards finding a suitable lead molecule in a drug discovery project; while the latter can meet their local demands of malaria, scientifically.
考虑到对抗疟植物的需求，找到并确定它们的位置以进行最佳提取变得至关重要。这项工作旨在寻找当地居民使用的具有抗疟活性的植物；提高研究区域普遍存在的传统知识体系（TKS）的价值；汇编用于疟疾治疗的当地植物（称为抗疟植物）的特征，并对其进行空间分布分析以建立地理健康概念。
根据文献调查和雨季期间从85名不同民族的受访者收集的实地数据列出抗疟植物。提取植物的民族药用用途；在与现有文献交叉验证后，记录植物的学名、科、当地名称、使用部位、民间传说、地理位置和图像。访谈分为实地、吠陀医生/哈基姆医生和挨家挨户三个部分。对主要植物科、使用的植物部位、人们和患者的反应以及民间传说进行了图形分析。通过三个植物指标对受访者的反应、植物鉴定方法和人们对传统知识体系的偏好进行了数学分析。
报告了属于27个科的51种植物及其地理属性。发现植物根（31.75%）最常用于疟疾治疗，给药方式主要是煎剂（41.2%）。研究区域以豆科（7种）、菊科（4种）、爵床科（4种）和苋科（4种）的植物为主。发现最受欢迎的植物是鸭嘴花、腊肠树和印度獐牙菜，而传统知识体系在疟疾治疗中的使用率为82.0%。
科学界和普通农村居民都可以利用这些研究结果来可持续地对这些自然资源进行生物发现。前者可以提取表格，以在药物发现项目中找到合适的植物来寻找合适的先导分子；而后者可以科学地满足他们当地对疟疾治疗的需求。
