Puri A, Saxena R, Saxena R P, Saxena K C, Srivastava V, Tandon J S
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
J Ethnopharmacol. 1994 Mar;42(1):31-7. doi: 10.1016/0378-8741(94)90020-5.
Nyctanthes arbor-tristis L. (Oleaceae), a plant widely used in the traditional medicinal systems of India, has recently been reported to possess hepatoprotective, antileishmanial, antiviral and antifungal activities. In the present study strong stimulation of antigen specific and non-specific immunity, as evidenced by increases in humoral and delayed type hypersensitivity (DTH) response to sheep red blood cells (SRBC) and in the macrophage migration index (MMI), has been demonstrated in mice fed with 50% ethanolic extract of seeds, flowers and leaves of this plant. Maximum activity was found in the seeds in which the active principle(s) appear to be mainly associated with lipids. In flowers and leaves, however, the major activity was found in the aqueous fraction of the 50% ethanol extract. The immunostimulant substance(s) found in N. arbor-tristis L. are likely to play a role in its antiamoebic, antileishmanial, antiviral and certain other activities.
夜花树（Nyctanthes arbor - tristis L.，木犀科）是一种在印度传统医学体系中广泛应用的植物，最近有报道称其具有保肝、抗利什曼原虫、抗病毒和抗真菌活性。在本研究中，给小鼠喂食该植物种子、花朵和叶子的50%乙醇提取物后，发现其对体液免疫以及对绵羊红细胞（SRBC）的迟发型超敏反应（DTH）增强，巨噬细胞游走指数（MMI）升高，从而证明对抗原特异性和非特异性免疫有强烈刺激作用。在种子中发现了最大活性，其中的活性成分似乎主要与脂质相关。然而，在花朵和叶子中，主要活性存在于50%乙醇提取物的水相部分。在夜花树中发现的免疫刺激物质可能在其抗阿米巴、抗利什曼原虫、抗病毒及其他某些活性中发挥作用。
