Yanagi Masahide, Kiuchi Yoshiaki, Yuasa Yuki, Yoneda Tsuyoshi, Sumi Tamaki, Hoshikawa Yasuhiro, Kobayashi Masahiko, Fukushima Atsuki
Department of Ophthalmology and Visual Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Department of Ophthalmology and Visual Science, Kochi University, Nankoku, Japan.
Jpn J Ophthalmol. 2016 Mar;60(2):72-7. doi: 10.1007/s10384-016-0426-4. Epub 2016 Feb 4.
We used an image analysis software program to quantitatively investigate conjunctival injection in patients treated with eye drops for glaucoma.
We compared 169 patients (89 men and 80 women) with a diagnosis of glaucoma. Photographs of the conjunctiva were taken on the temporal side of each patient's right eye using a slit lamp. We determined the mean pixel frequencies of the conjunctival blood vessels from the photographs.
The ocular hyperemia of the patients being treated with prostaglandins was more severe than that of the patients being treated with beta-blockers or no eye drops. In multiple comparisons of each of the eye drops, the control group had a significantly lower degree of hyperemia than did the patients being treated with each of the various prostaglandin analogs (latanoprost, travoprost, tafluprost, and bimatoprost). Among the patients receiving prostaglandin, the percentage of those with hyperemia was highest in the bimatoprost users, followed in order by the travoprost, latanoprost, and tafluprost users. However, no significant differences were found among the different prostaglandin analogs in terms of the percentage of patients with hyperemia.
Our software program may be useful for evaluating the hyperemic effects of eye drops used for glaucoma. The particular type of prostaglandin analog seems to determine the level of conjunctival hyperemia during ocular hypotensive medical treatment.
我们使用图像分析软件程序对接受青光眼滴眼液治疗的患者的结膜充血情况进行定量研究。
我们比较了169例诊断为青光眼的患者（89名男性和80名女性）。使用裂隙灯在每位患者右眼的颞侧拍摄结膜照片。我们从照片中确定结膜血管的平均像素频率。
接受前列腺素治疗的患者的眼部充血比接受β受体阻滞剂治疗或未使用滴眼液的患者更严重。在对每种滴眼液的多重比较中，对照组的充血程度明显低于接受各种前列腺素类似物（拉坦前列素、曲伏前列素、他氟前列素和比马前列素）治疗的患者。在接受前列腺素治疗的患者中，比马前列素使用者的充血百分比最高，其次依次是曲伏前列素、拉坦前列素和他氟前列素使用者。然而，在充血患者百分比方面，不同的前列腺素类似物之间未发现显著差异。
我们的软件程序可能有助于评估用于青光眼的滴眼液的充血效果。特定类型的前列腺素类似物似乎决定了眼压降低药物治疗期间结膜充血的程度。
