Department of Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence 'Campus Mare Nostrum', Murcia, Spain.
LabMET, Ghent University, Coupure links 653, 9000, Ghent, Belgium.
Curr Obes Rep. 2016 Mar;5(1):97-105. doi: 10.1007/s13679-016-0196-9.
The prevalence of overweight and obesity is increasing globally, driven by the availability of energy-dense palatable foods. Most dietary strategies fail because of hunger generated by calorie restriction, and interventions that specifically control hunger and/or promote fullness may aid success. Current consumers have a limited choice of satiety-enhancing products with proven health benefits, and innovative ways to produce new foods (as structural modification) to enhance satiety/satiation may provide new opportunities. However, this potential is hindered by the cost of product testing. Within the SATIN-SATiety INnovation project-an in vitro platform has been developed to offer a cost-effective means of assessing the potential satiation/satiety effect of novel foods. This combines in vitro technologies to assess changes in colonic bacteria metabolism, appetite hormone release and the stability and bioavailability of active compounds in the new products/ingredients. This article provides a brief review of nutrients for which an impact on short-term appetite regulation has been demonstrated, and a summary of the changes to food structure which can be used to produce a change in appetite expression. Furthermore, the SATIN in vitro platform is discussed as a means of assessing the impact of nutritional and structural manipulations on appetite.
超重和肥胖的流行率在全球范围内不断上升，这是由于高热量美味食物的供应所致。大多数饮食策略都因热量限制引起的饥饿而失败，而专门控制饥饿感和/或促进饱腹感的干预措施可能有助于成功。目前消费者对具有明确健康益处的增强饱腹感产品的选择有限，因此，创新的方法来生产新的食物（如结构修饰）以增强饱腹感可能提供新的机会。然而，这种潜力受到产品测试成本的限制。在 SATIN-SATiety INnovation 项目中，已经开发出一种体外平台，以提供一种经济有效的方法来评估新型食品的潜在饱腹感/饱腹感效应。该平台结合了体外技术，以评估结肠细菌代谢、食欲激素释放以及新产品/成分中活性化合物的稳定性和生物利用度的变化。本文简要回顾了已证明对短期食欲调节有影响的营养素，并总结了可用于改变食欲表达的食物结构变化。此外，还讨论了 SATIN 体外平台作为评估营养和结构处理对食欲影响的一种手段。
