Sharifabadi Ali Haidari, Haeri Hayedeh, Zeinalizadeh Mehdi, Zargari Neda, Razavi Amirnader Emami, Shahbazi Nargess, Tahvildari Malahat, Azmoudeh-Ardalan Farid
Pathology and Laboratory Medicine Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 14197-33141, Iran.
Neurosurgery Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 14197-33141, Iran.
Pathol Res Pract. 2016 Mar;212(3):179-84. doi: 10.1016/j.prp.2015.08.009. Epub 2015 Sep 5.
Frozen section is the traditional method of assessing central nervous system (CNS) lesions intraoperatively. Our aim is to determine the diagnostic accuracy of frozen section and/or cytological evaluation of CNS lesions in our center.
A total of 157 patients with CNS lesions underwent open surgical biopsy or excision in our center during a period of 2 years (2012-2013). All specimens were studied cytologically; of these specimens, 146 cases were also examined by frozen section. Cytology and frozen section slides were studied separately by two general pathologists who were blind to final diagnoses. The final diagnoses were based on permanent sections and IHC studies.
The accuracy rates of frozen section analysis and cytological evaluation were 87% and 86%, respectively. If the two methods were considered together, the accuracy rate improved to about 95%.
Cytological evaluation is an acceptable alternative to frozen section analysis and also a great supplement to the diagnosis of CNS lesions.
冰冻切片是术中评估中枢神经系统（CNS）病变的传统方法。我们的目的是确定我院中枢神经系统病变冰冻切片和/或细胞学评估的诊断准确性。
在2年期间（2012 - 2013年），我院共有157例中枢神经系统病变患者接受了开放性手术活检或切除。所有标本均进行了细胞学研究；其中146例标本还进行了冰冻切片检查。细胞学和冰冻切片玻片由两位对最终诊断不知情的普通病理学家分别进行研究。最终诊断基于永久切片和免疫组化研究。
冰冻切片分析和细胞学评估的准确率分别为87%和86%。如果将这两种方法结合考虑，准确率提高到约95%。
细胞学评估是冰冻切片分析可接受的替代方法，也是中枢神经系统病变诊断的重要补充。
