Department of Pathology, Moriyama Memorial Hospital, Tokyo, 134-0081, Japan.
Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Brain Tumor Pathol. 2023 Oct;40(4):215-221. doi: 10.1007/s10014-023-00470-9. Epub 2023 Oct 6.
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (IPD). They are invaluable tools for therapeutic decision-making, helping surgeons avoid under or overtreatment of patients. Pituitary neuroendocrine tumors (PitNETs) are generally small, slow-growing tumors with low-grade malignancy located at the base of the skull where it is impossible to maintain a wide tumor margin. Therefore, transsphenoidal surgery (TSS) should be performed with necessary caution, and with sufficient and minimal resection. Thus, this study aimed to evaluate the diagnostic accuracy of TIC for the diagnosis of PitNET and determine its ability to accurately evaluate the surgical margin compared to the FS procedure. A total of 104 fresh specimens from 28 patients who underwent TSS for PitNETs were examined using TIC and FS. TIC specimens were categorized according to the cell imprinting pattern. All specimens with a large number of neuroendocrine cells diffusely attached to the glass surfaces had PitNET components. Contrarily, no rich or diffuse cell attachments were observed in any non-tumoral endocrine cells. In conclusion, recognizing a pattern of endocrine cell adherence to glass is highly effective in IPD to certify the existence of a PitNET component.
触摸印片细胞学（TIC）和冷冻切片（FS）程序是术中病理诊断（IPD）的重要手段。它们是治疗决策的宝贵工具，帮助外科医生避免对患者的过度或不足治疗。垂体神经内分泌肿瘤（PitNETs）通常是位于颅底的小而生长缓慢的低度恶性肿瘤，因此无法保持肿瘤的宽切缘。因此，经蝶窦手术（TSS）应谨慎进行，并进行充分和最小限度的切除。因此，本研究旨在评估 TIC 诊断 PitNET 的诊断准确性，并确定其与 FS 程序相比准确评估手术切缘的能力。对 28 例经 TSS 治疗的 PitNET 患者的 104 个新鲜标本进行了 TIC 和 FS 检查。根据细胞印片模式对 TIC 标本进行分类。所有大量神经内分泌细胞弥漫性附着在玻璃表面的标本均具有 PitNET 成分。相反，在任何非肿瘤内分泌细胞中均未观察到丰富或弥漫性的细胞附着。总之，识别内分泌细胞附着在玻璃上的模式对于 IPD 中证实存在 PitNET 成分非常有效。
