Joyce G F
Salk Institute for Biological Studies, La Jolla, CA 92037.
Gene. 1989 Oct 15;82(1):83-7. doi: 10.1016/0378-1119(89)90033-4.
RNA, by virtue of its genotypic and phenotypic properties, is a suitable substrate for molecular evolution in the laboratory. We have developed techniques for the rapid amplification, mutation and selection of catalytic RNA. By combining these techniques in an iterative fashion, we are attempting to construct an RNA-based evolving system. Such a system could be used to explore the catalytic potential of RNA.
由于其基因型和表型特性，RNA是实验室中分子进化的合适底物。我们已经开发出了用于催化RNA快速扩增、突变和选择的技术。通过以迭代方式组合这些技术，我们正在尝试构建一个基于RNA的进化系统。这样的系统可用于探索RNA的催化潜力。
