Rising JCV-Ab index during natalizumab therapy for MS: Inauspicious for a highly efficacious drug.
作者信息
Javed Adil, Reder Anthony T
机构信息
University of Chicago, IL.
出版信息
Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(1):e199. doi: 10.1212/NXI.0000000000000199. eCollection 2016 Feb.
Abstract
摘要
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Rising JCV-Ab index during natalizumab therapy for MS: Inauspicious for a highly efficacious drug.多发性硬化症患者接受那他珠单抗治疗期间JCV抗体指数上升：这对一种高效药物来说并非吉兆。
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本文引用的文献
1
Therapy with natalizumab is associated with high JCV seroconversion and rising JCV index values.那他珠单抗治疗与高 JCV 血清转化率和 JCV 指数升高有关。
Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(1):e195. doi: 10.1212/NXI.0000000000000195. eCollection 2016 Feb.
2
Anti-JC virus antibody titres increase over time with natalizumab treatment.使用那他珠单抗治疗时，抗JC病毒抗体滴度会随时间增加。
Mult Scler. 2015 Dec;21(14):1833-8. doi: 10.1177/1352458515599681. Epub 2015 Oct 8.
4
Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab.用那他珠单抗治疗的多发性硬化症患者中进行进行性多灶性白质脑病（PML）预测的免疫标志物
Front Immunol. 2015 Jan 5;5:668. doi: 10.3389/fimmu.2014.00668. eCollection 2014.
5
Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy.血清或血浆中的抗JC病毒抗体水平进一步明确了那他珠单抗相关进展性多灶性白质脑病的风险。
Ann Neurol. 2014 Dec;76(6):802-12. doi: 10.1002/ana.24286. Epub 2014 Oct 24.
6
Anti-JC virus (JCV) antibody prevalence in the JCV Epidemiology in MS (JEMS) trial.多发性硬化症中JC病毒（JCV）流行病学（JEMS）试验中的抗JC病毒（JCV）抗体流行率。
Eur J Neurol. 2014 Feb;21(2):299-304. doi: 10.1111/ene.12304. Epub 2013 Nov 30.
7
JC-virus seroconversion in multiple sclerosis patients receiving natalizumab.接受那他珠单抗治疗的多发性硬化症患者的JC病毒血清转化
Mult Scler. 2014 Jun;20(7):822-9. doi: 10.1177/1352458513505353. Epub 2013 Sep 26.
8
Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort.抗 JC 病毒抗体在一个大型德国那他珠单抗治疗多发性硬化症队列中。
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