中国上海接触金属、溶剂、化学品和内毒素的女性纺织工人患胰腺癌的风险：一项巢式病例队列研究的随访
Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin: Follow-Up to a Nested Case-Cohort Study.
作者信息
Reul Nicholas K, Li Wenjin, Gallagher Lisa G, Ray Roberta M, Romano Megan E, Gao Daoli, Thomas David B, Vedal Sverre, Checkoway Harvey
机构信息
Department of Environmental and Occupational Health Sciences (Drs Gallagher, Vedal, and Checkoway); Department of Epidemiology (Drs Romano and Thomas), University of Washington; Program in Epidemiology (Drs Li and Thomas), Division of Public Health Sciences (Ms Ray), Fred Hutchinson Cancer Research Center, Seattle; Department of Epidemiology (Dr Gao), Zhongshan Hospital, Fu Dan University, Shanghai, China; and Department of Family and Preventive Medicine, University of California San Diego, La Jolla.
出版信息
J Occup Environ Med. 2016 Feb;58(2):195-9. doi: 10.1097/JOM.0000000000000596.
OBJECTIVE
We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort.
METHODS
We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design.
RESULTS
We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.
CONCLUSIONS
Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
目的
我们在中国上海的一组女性纺织工人队列中研究了胰腺癌与职业性接触金属、溶剂、化学物质和内毒素之间的关联。为评估这些因素对胰腺癌的长期影响，我们对这个先前研究过的队列进行了随访延长。
方法
我们使用工作暴露矩阵评估了481例胰腺癌病例以及随机选取的3191例非病例子队列的职业暴露情况。我们使用适用于病例队列设计的Cox比例风险模型计算风险比和95%置信区间。
结果
我们观察到与溶剂暴露相关的风险比呈统计学显著的上升趋势，但与包括内毒素和金属在内的其他职业暴露均无关联。
结论
我们关于溶剂暴露会增加胰腺癌风险的研究结果与已发表的文献一致。
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