Ding Wuxiao, Chechetka Svetlana A, Masuda Mitsutoshi, Shimizu Toshimi, Aoyagi Masaru, Minamikawa Hiroyuki, Miyako Eijiro
Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.
Nanomaterials Research Institute, AIST, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.
Chemistry. 2016 Mar 18;22(13):4345-50. doi: 10.1002/chem.201504958. Epub 2016 Feb 5.
Helically coiled and linear polydopamine (PDA) nanofibers were selectively fabricated with two different types of lipid nanotubes (LNTs) that acted as templates. The obtained coiled PDA-LNT hybrid showed morphological advantages such as higher light absorbance and photothermal conversion effect compared to a linear counterpart. Laser irradiation of the coiled PDA-LNT hybrid induced a morphological change and subsequent release of the encapsulated guest molecule. In cellular experiments, the coiled PDA-LNT efficiently eliminated HeLa cells because of its strong affinity with the tumor cells. This work illustrates the first approach to construct characteristic morphologies of PDA nanofibers using LNTs as simple templates, and the coiled PDA-LNT hybrid exhibits attractive photothermal features derived from its unique coiled shape.
利用两种不同类型的脂质纳米管（LNTs）作为模板，选择性地制备了螺旋状和线性聚多巴胺（PDA）纳米纤维。与线性对应物相比，所获得的螺旋状PDA-LNT杂化物具有形态学优势，如更高的吸光度和光热转换效应。对螺旋状PDA-LNT杂化物进行激光照射会引起形态变化以及随后包封客体分子的释放。在细胞实验中，螺旋状PDA-LNT因其与肿瘤细胞的强亲和力而有效地消除了HeLa细胞。这项工作展示了使用LNTs作为简单模板构建PDA纳米纤维特征形态的第一种方法，并且螺旋状PDA-LNT杂化物因其独特的螺旋形状而展现出有吸引力的光热特性。
