Patuzzi R B, Yates G K, Johnstone B M
Department of Physiology, University of Western Australia, Nedlands.
Hear Res. 1989 Oct;42(1):47-72. doi: 10.1016/0378-5955(89)90117-2.
It is argued in this paper that many nonlinear phenomena in audition and many types of sensorineural hearing loss can be explained by a disruption of the mechano-electrical transduction process at the apex of the outer hair cells. This is done using experimental data and a simple model of the active role of outer hair cells in cochlear mechanics based on our previous experiments with acoustic trauma. The causes of sensorineural loss addressed include acoustic trauma, aminoglycoside ototoxicity, intoxication with loop diuretics, hypoxia and Meniere's disease. The nonlinear phenomena discussed include loudness compression, two-tone suppression and modulation of cochlear sensitivity by very low-frequency tones. In every case considered the reduction in neural sensitivity was related to the reduction in outer hair cell receptor current in a quantitatively similar way. We conclude that the link is causal.
本文认为，听觉中的许多非线性现象以及许多类型的感音神经性听力损失，可以通过外毛细胞顶端机械-电转导过程的破坏来解释。这是通过实验数据以及基于我们之前声学创伤实验的外毛细胞在耳蜗力学中主动作用的简单模型来完成的。所探讨的感音神经性听力损失的病因包括声学创伤、氨基糖苷类耳毒性、袢利尿剂中毒、缺氧和梅尼埃病。所讨论的非线性现象包括响度压缩、双音抑制以及极低频音调对耳蜗敏感性的调制。在每种情况下，神经敏感性的降低与外毛细胞受体电流的降低在数量上以相似的方式相关。我们得出结论，这种联系是因果关系。
