Baek Jeong-In, Kim Ye-Ri, Lee Kyu-Yup, Kim Un-Kyung
Department of Companion Animal Health, College of Rehabilitation and Health, Daegu Haany University, Gyeongsan, Republic of Korea.
Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.
Front Pharmacol. 2023 Mar 31;14:1176881. doi: 10.3389/fphar.2023.1176881. eCollection 2023.
Noise (noise-induced hearing loss), and ototoxic drugs (drug-induced ototoxicity), and aging (age-related hearing loss) are the major environmental factors that lead to acquired sensorineural hearing loss. So far, there have been numerous efforts to develop protective or therapeutic agents for acquired hearing loss by investigating the pathological mechanisms of each types of hearing loss, especially in cochlear hair cells and auditory nerves. Although there is still a lack of information on the underlying mechanisms of redox homeostasis and molecular redox networks in hair cells, an imbalance in mitochondrial reactive oxygen species (ROS) levels that enhance oxidative stress has been suggested as a key pathological factor eventually causing acquired sensorineural hearing loss. Thus, various types of antioxidants have been investigated for their abilities to support auditory cells in maintenance of the hearing function against ototoxic stimuli. In this review, we will discuss the scientific possibility of developing drugs that target particular key elements of the mitochondrial redox network in prevention or treatment of noise- and ototoxic drug-induced hearing loss.
噪声（噪声性听力损失）、耳毒性药物（药物性耳毒性）和衰老（年龄相关性听力损失）是导致后天性感音神经性听力损失的主要环境因素。到目前为止，通过研究每种类型听力损失的病理机制，特别是在耳蜗毛细胞和听神经方面，人们已经做出了许多努力来开发针对后天性听力损失的保护或治疗药物。尽管关于毛细胞中氧化还原稳态和分子氧化还原网络的潜在机制仍缺乏信息，但线粒体活性氧（ROS）水平失衡导致氧化应激增强已被认为是最终导致后天性感音神经性听力损失的关键病理因素。因此，人们研究了各种类型的抗氧化剂，以了解它们在支持听觉细胞维持听力功能以抵抗耳毒性刺激方面的能力。在这篇综述中，我们将讨论开发针对线粒体氧化还原网络特定关键元素的药物在预防或治疗噪声和耳毒性药物引起的听力损失方面的科学可能性。
