Souverein Dennis, Houtman Patricia, Euser Sjoerd M, Herpers Bjorn L, Kluytmans Jan, Den Boer Jeroen W
Department of Epidemiology and Infection Prevention, Regional Public Health Laboratory Kennemerland, Haarlem, the Netherlands.
Department of Infection Control, Kennemer Gasthuis, Haarlem, The Netherlands.
PLoS One. 2016 Feb 5;11(2):e0148175. doi: 10.1371/journal.pone.0148175. eCollection 2016.
The objective of this study was to analyze the costs and benefits of the MRSA Search and Destroy (S&D) policy between 2008 and 2013 in the Kennemer Gasthuis, a 400 bed teaching hospital in the region Kennemerland, the Netherlands.
A patient registration database was used to retrospectively calculate costs, including screening, isolation, follow-up, contact tracing, cleaning, treatment, deployment of extra healthcare workers, salary for an infection control practitioner (ICP) and service of isolation rooms. The estimated benefits (costs and lives when no MRSA S&D was applied) were based on a varying MRSA prevalence rate (up to 50%).
When no MRSA S&D policy was applied, the additional costs and deaths due to MRSA bacteraemia were estimated to be € 1,388,907 and 33 respectively (at a MRSA prevalence rate of 50%). Currently, the total costs were estimated to be € 290,672 (€ 48,445 annually) and a MRSA prevalence rate of 17.3% was considered as break-even point. Between 2008 and 2013, a total of 576 high risk patients were screened for MRSA carriage, of whom 19 (3.3%) were found to be MRSA positive. Forty-nine patients (72.1%) were found unexpectedly.
Application of the MRSA S&D policy saves lives and money, although the high rate of unexpected MRSA cases is alarming.
本研究旨在分析2008年至2013年期间,荷兰肯内默兰地区一家拥有400张床位的教学医院——肯内默加斯huis实施耐甲氧西林金黄色葡萄球菌(MRSA)筛查与清除(S&D)政策的成本与效益。
利用患者登记数据库回顾性计算成本,包括筛查、隔离、随访、接触者追踪、清洁、治疗、额外医护人员的调配、感染控制专员(ICP)的薪资以及隔离病房的服务。估计的效益(若未实施MRSA S&D政策时的成本和生命损失)基于不同的MRSA流行率(高达50%)。
若未实施MRSA S&D政策,因MRSA菌血症导致的额外成本和死亡人数估计分别为1,388,907欧元和33人(MRSA流行率为50%时)。目前,总成本估计为290,672欧元(每年48,445欧元),MRSA流行率为17.3%被视为盈亏平衡点。2008年至2013年期间,共对576名高危患者进行了MRSA携带筛查,其中19人(3.3%)被发现为MRSA阳性。49名患者(72.1%)是意外发现的。
实施MRSA S&D政策可挽救生命并节省资金,尽管意外MRSA病例的高发生率令人担忧。