Tang Hong, Li Yong, Zhang Pingping, Guo Jiayin, Huang Zheng, Xu Hao, Hou Qi, Wang Chuanqing, Zeng Mei, Jin Huiming, Hu Jiayu, Shi Xianming, Zhang Jianmin, Kan Biao, Xiong Yanwen, Zhao Ailan, Ran Lu, Xu Xuebin
Changning District Center for Disease Control and Prevention, Shanghai 200051, China.
Putuo District Center of Disease Control and Prevention.
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Nov;36(11):1263-8.
To understand the distribution of diarrheagenic Escherichia (E.) coli in population in Shanghai and discuss the practice model of cooperation in enteric infectious disease prevention and control between public health institution and hospital.
Sentinel hospitals were assigned, standard detection and identification of diarrheagenic E. coli were conducted, incidence curve of diarrheagenic E. coli infection was drawn and epidemiologic survey and laboratory detection were conducted for suspect diarrheagenic E. coli infection outbreaks.
A total of 7 204 stool specimens were collected from diarrhea patients in 4 hospitals during 2012-2013, in which 712 (9.9% ) were diarrheagenic E. coli positive, including 351 enteropathogenic E. coli (EPEC) strains, 292 enterotoxigenic E. coli (ETEC) strains, 32 enteroinvasive E. coli(EIEC) strains and 6 Shiga toxin-producing E. coli (STEC/EHEC) strains, as well as 31 mixed strains. EPEC infection mainly occurred in children aged 1-5 years; and all of these infections were caused by aEPEC. The incidence peak of ETEC infection was during August, the positive rate was >20%. The ETEC infection mainly occurred in infants aged 1-28 days in 2012 and in people aged 20-60 years in 2013 (P<0.05). ST was the major type (59.6%), followed by LT (27.8%) and ST/LT (12.6%). EIEC infection increased in children obviously in 2013 (P<0.01). No EHEC O157:H7 case was detected, but two EHEC O26:H11 (eae-hlyA-stx1a) cases in children were reported for the first time in Shanghai. The survey result indicated that the multidrug-resistant ETEC (STh-CS21-CFA/I-ClyA-EatA-ST2332-SHNL0005) strain causing outbreak in 15 newborns in Shanghai in 2012 was in the same clone as the strain detected in Zigong in Sichuan province.
Significant change has occurred in diarrheagenic E. coli distribution in Shanghai in recent years, ETEC has potential risk to cause outbreak of hospital acquired infection in neonates and food borne infection. The active surveillance on ETEC and other enteric pathogens by both public health institutions and hospitals need to be improved.
了解上海市人群中致泻性大肠埃希菌的分布情况，探讨公共卫生机构与医院在肠道传染病防控方面的合作实践模式。
指定哨点医院，对致泻性大肠埃希菌进行标准检测与鉴定，绘制致泻性大肠埃希菌感染发病率曲线，并对疑似致泻性大肠埃希菌感染暴发进行流行病学调查和实验室检测。
2012 - 2013年期间，从4家医院腹泻患者中共采集7204份粪便标本，其中712份（9.9%）致泻性大肠埃希菌阳性，包括351株肠致病性大肠埃希菌（EPEC）、292株肠产毒性大肠埃希菌（ETEC）、32株肠侵袭性大肠埃希菌（EIEC）、6株产志贺毒素大肠埃希菌（STEC/EHEC）以及31株混合菌株。EPEC感染主要发生在1 - 5岁儿童中，且均由非典型EPEC引起。ETEC感染发病高峰在8月，阳性率>20%。ETEC感染在2012年主要发生在1 - 28天的婴儿中，2013年主要发生在2
