Kisacik Pinar, Unal Edibe, Akman Umit, Yapali Gokmen, Karabulut Erdem, Akdogan Ali
Hacettepe University, Faculty of Health Science, Physiotehrapy and Rehabilitation Department, Ankara, Turkey.
Hacettepe University Hospitals, Department of Internal Medicine, Hematology Unit, Ankara, Turkey.
Complement Ther Clin Pract. 2016 Feb;22:38-43. doi: 10.1016/j.ctcp.2015.11.002. Epub 2015 Dec 2.
The purpose of this study is to investigate the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis (AS).
The BATH Indexes, Dougados Functional Index (DFI), Health Assessment Questionnaire in Spondyloarthopathies (HAQ-S), Ankylosing Spondylitis Quality of Life (ASQoL) and Beck Depression Inventory (BDI) were used to evaluate twenty-four female AS patients. ESR, CRP, TNF-α and IL-6 were also analyzed. All patients were assessed at baseline and with 3 weeks intervals till 12 week. A multidimensional exercise program was applied for three times a week.
There were significant differences in Bath Ankylosing Spondylitis Global Index (BAS-G) and Disease Activity Index (BASDAI), HAQ-S, ASQoL and BDI scores (p < 0.05). The level of the ESR, CRP and IL-6 fluctuated slightly. There was only significant difference at 3 and 12 weeks as compared to baseline levels in TNF-α values (p = 0.048, p < 0.001).
We concluded that multidimensional exercise program should be taken into consideration for AS patients due to its positive effects on symptoms and antiinflammatory effects.
本研究旨在调查多维运动计划对女性强直性脊柱炎（AS）患者症状及抗炎状态的影响。
采用巴斯指数、杜加多斯功能指数（DFI）、脊柱关节病健康评估问卷（HAQ-S）、强直性脊柱炎生活质量（ASQoL）和贝克抑郁量表（BDI）对24例女性AS患者进行评估。同时分析血沉（ESR）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）。所有患者在基线时进行评估，并每隔3周评估一次，直至12周。多维运动计划每周实施3次。
巴斯强直性脊柱炎整体指数（BAS-G）、疾病活动指数（BASDAI）、HAQ-S、ASQoL和BDI评分存在显著差异（p < 0.05）。ESR、CRP和IL-6水平略有波动。与基线水平相比，TNF-α值仅在3周和12周时有显著差异（p = 0.048，p < 0.001）。
我们得出结论，由于多维运动计划对症状有积极影响且具有抗炎作用，AS患者应考虑采用该计划。
