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体重减轻对胃癌根治性胃切除术后复发的影响。

Impact of Body Weight Loss on Recurrence After Curative Gastrectomy for Gastric Cancer.

作者信息

Kubo Hidemasa, Komatsu Shuhei, Ichikawa Daisuke, Kawaguchi Tsutomu, Kosuga Toshiyuki, Okamoto Kazuma, Konishi Hirotaka, Shiozaki Atsushi, Fujiwara Hitoshi, Otsuji Eigo

机构信息

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

出版信息

Anticancer Res. 2016 Feb;36(2):807-13.

Abstract

BACKGROUND

This study was designed to assess the prognostic role of body weight loss (BWL) after curative gastrectomy for gastric cancer patients.

PATIENTS AND METHODS

We analyzed a total of 102 consecutive patients who underwent curative gastrectomy for stage II or III gastric cancer between 2005 and 2011. Postoperative BWL during the first 6 months in patients was calculated from their hospital records.

RESULTS

Postoperative BWL was significantly higher in patients with tumours in the upper stomach, total gastrectomy, or subsequent recurrence. A postoperative BWL of 12% was the optimal cut-off value, which was strongly associated with subsequent recurrence. Patients with a postoperative BWL of 12% or higher did not have poorer overall survival but did have significantly poorer disease-free survival than patients with BWL of less than 12%. Cox proportional hazard analyses revealed that a postoperative BWL of 12% or higher was an independent prognostic factor of poor disease-free survival.

CONCLUSION

High BWL after curative gastrectomy is related to recurrence in patients with gastric cancer.

摘要

背景

本研究旨在评估胃癌患者根治性胃切除术后体重减轻(BWL)的预后作用。

患者与方法

我们分析了2005年至2011年间连续接受根治性胃切除术的102例II期或III期胃癌患者。根据患者的医院记录计算其术后前6个月的BWL。

结果

上胃癌、全胃切除术或术后复发患者的术后BWL显著更高。术后BWL为12%是最佳临界值,与随后的复发密切相关。术后BWL为12%或更高的患者总体生存率并不更低,但与BWL低于12%的患者相比,无病生存率显著更低。Cox比例风险分析显示,术后BWL为12%或更高是无病生存不良的独立预后因素。

结论

根治性胃切除术后高BWL与胃癌患者的复发有关。

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