佛手柑对血脂异常的影响。

The effect of bergamot on dyslipidemia.

作者信息

Giglio Rosaria Vincenza, Patti Angelo Maria, Nikolic Dragana, Li Volti Giovanni, Al-Rasadi Khalid, Katsiki Niki, Mikhailidis Dimitri P, Montalto Giuseppe, Ivanova Ekaterina, Orekhov Alexander N, Rizzo Manfredi

机构信息

Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Palermo, Italy.

Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.

出版信息

Phytomedicine. 2016 Oct 15;23(11):1175-81. doi: 10.1016/j.phymed.2015.12.005. Epub 2015 Dec 30.

DOI:10.1016/j.phymed.2015.12.005

PMID:26851838

Abstract

BACKGROUND

Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds.

PURPOSE

This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans.

MAIN EVIDENCE

This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear.

CONCLUSION

It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

摘要

背景

他汀类药物是最常用的降脂药物，但它们可能会引起不良反应，尽管其治疗益处已得到充分证实，但心血管（CV）残余风险仍然存在。在这种情况下，单独使用其他降脂药物和营养保健品或作为附加的脂质调节疗法可能是一种选择。几项研究报告了柑橘类水果的健康相关特性，其中佛手柑（Citrus bergamia Risso）因其某些化合物的含量特别高而与其他水果不同。