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基于网络药理学和分子对接的复方丹参滴丸治疗高原性心脏病的作用机制及分子靶点

Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking.

作者信息

Yan Jiayi, Ruan Panpan, Ge Yunxuan, Gao Jing, Tan Hongling, Xiao Chengrong, Gao Quansheng, Zhang Zhuo, Gao Yue

机构信息

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.

出版信息

ACS Omega. 2021 Oct 5;6(41):26942-26951. doi: 10.1021/acsomega.1c03282. eCollection 2021 Oct 19.

DOI:10.1021/acsomega.1c03282
PMID:34693115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8529605/
Abstract

Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecular docking, and validation experiments were combined to investigate the effective active ingredients and molecular mechanisms of CDDP in the treatment of high-altitude heart disease. Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways.

摘要

复方丹参滴丸（CDDP）是一种著名的中药配方，在中国已被广泛用于治疗高原心脏病。然而，其分子机制、潜在靶点和生物活性成分仍不清楚。在本研究中，结合网络药理学、分子对接和验证实验，研究CDDP治疗高原心脏病的有效活性成分和分子机制。丹参酮IIA可能是CDDP通过HIF-1/PI3K/Akt途径治疗高原心脏病的主要活性成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/005c8e024130/ao1c03282_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/92f38583d617/ao1c03282_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/0b38bf655f7e/ao1c03282_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/54803d16bb76/ao1c03282_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/6f8f5f886f5a/ao1c03282_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/53c64b39e4e7/ao1c03282_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/5d99d8321074/ao1c03282_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/005c8e024130/ao1c03282_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/92f38583d617/ao1c03282_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/0b38bf655f7e/ao1c03282_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/54803d16bb76/ao1c03282_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/6f8f5f886f5a/ao1c03282_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/53c64b39e4e7/ao1c03282_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/5d99d8321074/ao1c03282_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8529605/005c8e024130/ao1c03282_0011.jpg

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