Ganz W I, Serafini A N
Department of Radiology, University of Miami School of Medicine, Florida.
J Nucl Med. 1989 Dec;30(12):1935-45.
This paper is a review of (a) the pathophysiology of the autoimmune deficiency syndrome (AIDS), and (b) the diagnostic procedures nuclear medicine has to evaluate human immunodeficiency virus related disorders. This article is organized in an organ system approach to AIDS pathology. The application of [67Ga]citrate, 111In-labeled white blood cells, [201Tl]chloride, single photon emission computed tomographic, and positron emission tomographic brain agents, [99mTc]sulfur colloid and [99mTc]methylene diphosphonate to the pulmonary, nervous, gastrointestinal, dermatologic, musculoskeletal, and renal systems is discussed. These radioisotopes allow earlier diagnosis than routine radiographic studies, and can monitor the effect of therapy on disease activity. In this review an attempt is made to provide clinically useful algorithms to suggest a specific pathogen based on the pattern of radionuclidic uptake.
（a）自身免疫缺陷综合征（艾滋病）的病理生理学，以及（b）核医学用于评估人类免疫缺陷病毒相关疾病的诊断程序。本文采用器官系统方法来阐述艾滋病病理学。讨论了[67Ga]枸橼酸盐、111In标记的白细胞、[201Tl]氯化物、单光子发射计算机断层扫描和正电子发射断层扫描脑显像剂、[99mTc]硫胶体和[99mTc]亚甲基二膦酸盐在肺、神经、胃肠、皮肤、肌肉骨骼和肾脏系统中的应用。这些放射性同位素比常规放射学检查能更早地做出诊断，并且可以监测治疗对疾病活动的影响。在本综述中，试图提供临床上有用的算法，以便根据放射性核素摄取模式来提示特定病原体。
