a Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology , Faculty of Biotechnology, Jeju National University , Jeju , Republic of Korea.
b Division of Veterinary Medicine , Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology , R. S. Pura, Jammu , India.
Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3449-3463. doi: 10.1080/10408398.2015.1129310.
Recent years have seen an unpretending increase in research using dietary phytochemicals for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional chemotherapy and radiotherapy and numerous associated side effects. A large number of dietary phytochemicals using traditional recommendation and experimental approaches have been demonstrated to have anti-proliferative, anti-metastatic, reactive oxygen species (ROS) inducing, anti-angiogenic, pro-apoptotic effects and efficacy in targeting cellular molecules and pathways implicated in malignancy. Researchers have shown the knack of phytochemicals in interfering with the CSCs self-renewal process. Thus, dietary phytochemicals can play a significant role in the cancer therapy owing to the plethora of targets without toxicity. In this review, we have discussed about the basic knowledge of CSCs, their identification, characterization, mechanism of self-renewal pathways (Wnt/β-catenin, Hedgehog, and Notch), features that help in the survival of CSCs and use of phytochemicals to replace chemotherapy. Applications of phytochemicals including curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, lycopene, and sulforaphane for their effect on targeting cancer and in particular CSCs along with their molecular mechanisms responsible for pharmacological action are also discussed.
近年来，由于传统化疗和放疗效果有限且存在许多相关副作用，利用膳食植物化学物靶向癌症和癌症干细胞（CSC）的研究逐渐增多。大量使用传统推荐和实验方法的膳食植物化学物质已被证明具有抗增殖、抗转移、诱导活性氧（ROS）、抗血管生成、促凋亡作用，并能有效靶向与恶性肿瘤相关的细胞分子和途径。研究人员已经发现植物化学物质在干扰 CSC 自我更新过程方面的诀窍。因此，由于无毒的大量靶点，膳食植物化学物质可以在癌症治疗中发挥重要作用。在这篇综述中，我们讨论了 CSC 的基础知识，包括它们的鉴定、特征、自我更新途径（Wnt/β-catenin、Hedgehog 和 Notch）的机制、有助于 CSC 存活的特征以及植物化学物质替代化疗的用途。还讨论了植物化学物质的应用，包括姜黄素、表没食子儿茶素-3-没食子酸酯（EGCG）、白藜芦醇、番茄红素和萝卜硫素，以及它们靶向癌症特别是 CSC 的作用及其负责药理作用的分子机制。
