Xu Xue-Ling, Deng Shou-Long, Lian Zheng-Xing, Yu Kun
Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
Antioxidants (Basel). 2021 Oct 28;10(11):1718. doi: 10.3390/antiox10111718.
Ovarian cancer is a heterogeneous disease and is also the major cause of death among women from gynecologic malignancies. A combination of surgery and chemotherapy is the major therapy for ovarian cancer. Unfortunately, despite good response rates to initial surgery and chemotherapy, most patients relapse and have a generally poor survival rate. The present research sheds light on the therapeutic effects of multiple natural products in patients with ovarian cancer. Notably, these natural ingredients do not have adverse effects on healthy cells and tissues, indicating that natural products can serve as a safe alternative therapy for ovarian cancer. -3,4,5'-Trihydroxystibene (resveratrol) is a natural product that is commonly found in the human diet and that has been shown to have anticancer effects on various human cancer cells. This review summarizes current knowledge regarding the progress of resveratrol against tumor cell proliferation, metastasis, apoptosis induction, autophagy, sensitization, and antioxidation as well as anti-inflammation. It also provides information regarding the role of resveratrol analogues in ovarian cancer. A better understanding of the role of resveratrol in ovarian cancer may provide a new array for the prevention and therapy of ovarian cancer.
卵巢癌是一种异质性疾病，也是女性妇科恶性肿瘤死亡的主要原因。手术和化疗相结合是卵巢癌的主要治疗方法。不幸的是，尽管对初始手术和化疗有良好的反应率，但大多数患者会复发，总体生存率普遍较低。目前的研究揭示了多种天然产物对卵巢癌患者的治疗效果。值得注意的是，这些天然成分对健康细胞和组织没有不良影响，这表明天然产物可作为卵巢癌的一种安全替代疗法。白藜芦醇是一种在人类饮食中常见的天然产物，已被证明对各种人类癌细胞具有抗癌作用。本综述总结了目前关于白藜芦醇在抑制肿瘤细胞增殖、转移、诱导凋亡、自噬、增敏、抗氧化以及抗炎方面进展的相关知识。它还提供了关于白藜芦醇类似物在卵巢癌中的作用的信息。更好地理解白藜芦醇在卵巢癌中的作用可能为卵巢癌的预防和治疗提供新的途径。
