Buist Harrie E, Krul Lisette, Leeman Winfried R
TNO, PO Box 360, 3700 AJ Zeist, The Netherlands.
TNO, PO Box 360, 3700 AJ Zeist, The Netherlands.
Regul Toxicol Pharmacol. 2016 Apr;76:217-20. doi: 10.1016/j.yrtph.2016.01.022. Epub 2016 Feb 4.
To derive an acute TTC threshold, the correlation between Allowable Daily Intakes (ADIs, chronic values) and Acute Reference Doses (ARfDs) of pesticides evaluated in the EU was investigated and their distributions were compared. The correlation between ARfDs and ADIs was significant (p = 0.01), but weak (r(2) = 0.051). Consequently, using this approach to derive acute TTC values does not seem valid. Therefore, the distributions of ARfDs and ADIs were compared directly, in order to extrapolate from chronic to acute TTC values. This comparison made for the combined Cramer structural class II and III pesticides showed a ratio ARfD/ADI of approximately 3 at the fifth percentile of the distributions. Based on these results, it is justified to propose a TTC for acute effects for Cramer III substances by multiplying the Cramer class III TTC threshold of 90 μg/person/day with a factor 3. This leads to an acute TTC threshold based on the Munro dataset for Cramer class III substances of 270 μg/person/day.
为得出急性经皮毒性阈值（TTC），研究了欧盟评估的农药每日允许摄入量（ADI，慢性值）与急性参考剂量（ARfD）之间的相关性，并比较了它们的分布情况。ARfD与ADI之间的相关性显著（p = 0.01），但较弱（r² = 0.051）。因此，用这种方法得出急性TTC值似乎并不有效。所以，直接比较了ARfD和ADI的分布，以便从慢性TTC值推断急性TTC值。对克莱默结构分类II和III农药的综合比较显示，在分布的第五百分位数处，ARfD/ADI的比值约为3。基于这些结果，通过将克莱默III类物质的TTC阈值90μg/人/天乘以3来提出克莱默III类物质急性效应的TTC是合理的。这就得出了基于门罗数据集的克莱默III类物质急性TTC阈值为270μg/人/天。
