School of the Environment, Trent University, Peterborough, ON K9L 0G2, Canada; Water Quality Centre, Trent University, Peterborough, ON K9L 0G2, Canada.
School of the Environment, Trent University, Peterborough, ON K9L 0G2, Canada.
Environ Toxicol Pharmacol. 2016 Mar;42:163-9. doi: 10.1016/j.etap.2016.01.007. Epub 2016 Jan 13.
Despite the importance of methylmercury (MeHg) as a neurotoxin, we have relatively few good data on partitioning and kinetics of MeHg among organs, particularly across the blood-brain barrier, for mammals that consume large quantities of fish. The objective of this study was to determine the partition coefficients between blood and brain, liver and kidney and fur for MeHg under steady-state conditions and to measure the half-lives for MeHg in these organs. Captive mink (Neovison vison) were fed a diet enriched with two stable isotopes of Hg, Me(199)Hg and Me(201)Hg for a period of 60 days. After a period of 10 days the diet was changed to contain only Me(201)Hg so that, between days 10 and 60, we were able to measure both uptake and elimination rates from blood, brain, liver kidney and fur. Liver and kidney response was very rapid, closely following changes in blood concentrations but there was a small lag time between peak blood concentrations and peak brain concentrations. Half-lives for MeHg were 15.4, 10.2 and 13.4 days for brain, liver and kidney, respectively. There was no measurable conversion of the MeHg to inorganic Hg (IHg) in the brain over the 60 day period, unlike in liver and kidney.
尽管甲基汞（MeHg）作为一种神经毒素非常重要，但我们对于哺乳动物在大量摄食鱼类的情况下，其器官（特别是血脑屏障）中 MeHg 的分配和动力学仍然知之甚少。本研究的目的是确定在稳态条件下 MeHg 在血液与大脑、肝脏和肾脏以及皮毛之间的分配系数，并测量这些器官中 MeHg 的半衰期。我们用富含两种稳定同位素 Hg 的饮食（Me(199)Hg 和 Me(201)Hg）饲养圈养水貂（Neovison vison） 60 天。在 10 天的时间后，饮食改为仅含 Me(201)Hg，以便在第 10 天到第 60 天之间，我们能够测量血液、大脑、肝脏、肾脏和皮毛中的吸收和消除率。肝脏和肾脏的反应非常迅速，与血液浓度的变化密切相关，但大脑中血液浓度峰值和大脑浓度峰值之间存在微小的滞后时间。MeHg 在大脑、肝脏和肾脏中的半衰期分别为 15.4、10.2 和 13.4 天。与肝脏和肾脏不同，在 60 天的时间内，大脑中没有可测量的 MeHg 向无机汞（IHg）的转化。
