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碳酸铯引发的查耳酮和酮的三氟甲基化反应用于三氟甲基化叔丁基硅醚的实际合成

Cs₂CO₃-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers.

作者信息

Dong Cheng, Bai Xing-Feng, Lv Ji-Yuan, Cui Yu-Ming, Cao Jian, Zheng Zhan-Jiang, Xu Li-Wen

机构信息

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.

出版信息

Molecules. 2017 May 18;22(5):769. doi: 10.3390/molecules22050769.

DOI:10.3390/molecules22050769
PMID:28524100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6154635/
Abstract

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.

摘要

研究发现，在催化量碳酸铯存在下，使用普拉卡什试剂可轻松实现酮、烯酮和醛的1,2 - 三氟甲基化反应，这对于不可烯醇化的醛和酮的阴离子三氟甲基化而言，是一种实验操作简便且原子经济的过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/08f1d34c12e7/molecules-22-00769-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/bae9daa00f52/molecules-22-00769-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/ee08ce59ac43/molecules-22-00769-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/91e4352fac91/molecules-22-00769-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/76ed9440e56e/molecules-22-00769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/c5df536e177b/molecules-22-00769-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/08f1d34c12e7/molecules-22-00769-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/bae9daa00f52/molecules-22-00769-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/ee08ce59ac43/molecules-22-00769-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/91e4352fac91/molecules-22-00769-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/76ed9440e56e/molecules-22-00769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/c5df536e177b/molecules-22-00769-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ba/6154635/08f1d34c12e7/molecules-22-00769-sch005.jpg

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