Al Moustafa Ala-Eddin, Mfoumou Etienne, Roman Dacian E, Nerguizian Vahe, Alazzam Anas, Stiharu Ion, Yasmeen Amber
College of Medicine & Biomedical Research Centre, Qatar University, Doha, Qatar; Oncology Department, McGill University, Montreal, QC, Canada; Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada; Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria.
Nova Scotia Community College, Dartmouth, NS, Canada.
Int J Nanomedicine. 2016 Jan 21;11:349-55. doi: 10.2147/IJN.S96361. eCollection 2016.
Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell-cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours.
碳纳米管（CNTs）因其独特的物理化学特性以及在各种工业产品和医学应用中的适用性，被认为是21世纪最具吸引力的材料之一。然而，在过去几年中，人们对碳纳米管对人类和环境的潜在毒性提出了质疑；据信，这些材料的物理化学特性是碳纳米管与活细胞相互作用的关键决定因素，因此也决定了它们对人类和其他生物体及其胚胎的毒性。因此，包括我们的研究在内的几项近期研究指出，碳纳米管对人类和动物细胞具有细胞毒性作用，这种作用是通过改变细胞增殖、凋亡、存活、细胞间粘附和血管生成的关键调节基因而发生的。与此同时，少数研究表明，碳纳米管对胚胎的正常发育也可能有害。在这篇综述中，我们将讨论单壁碳纳米管在胚胎中的毒性作用，这是包括我们团队在内的几个研究小组最近探索的内容。
