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[儿童和成人肝肾受累的临床综合征]

[Clinical syndromes with liver and kidney involvement in children and adults].

作者信息

Ehrich J H, Brunkhorst R, Burdelski M, Ringe B, Kühn K

机构信息

Kinderklinik, Medizinischen Hochschule Hannover.

出版信息

Monatsschr Kinderheilkd. 1989 Oct;137(10):649-56.

PMID:2685579
Abstract

Multiple pathogenetic mechanisms can lead to dysfunctions or malformations of the liver and kidneys in children and adults. The association of renal and hepatic abnormalities can be found in different congenital malformation syndromes. Hereditary metabolic disorders are capable of alternating liver and kidney function. Immunologic, toxic and septic diseases may damage both organ systems. In patients with liver cirrhosis, both glomerular and tubular dysfunctions can be observed. In the course of liver transplantations, an increased rate of renal dysfunction was observed. This survey summarizes the main clinical syndromes of renal involvement associated with liver disease.

摘要

多种致病机制可导致儿童和成人的肝脏和肾脏功能障碍或畸形。肾脏和肝脏异常的关联可见于不同的先天性畸形综合征。遗传性代谢紊乱能够改变肝脏和肾脏功能。免疫性、中毒性和感染性疾病可能损害这两个器官系统。在肝硬化患者中,可观察到肾小球和肾小管功能障碍。在肝移植过程中,观察到肾功能障碍的发生率增加。本综述总结了与肝脏疾病相关的肾脏受累的主要临床综合征。

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