Schleiss Mark R
Center for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases and Immunology, University of Minnesota Medical School, 2001 6(th) Street SE, Minneapolis, MN 55455, USA.
Trends Microbiol. 2016 Mar;24(3):170-172. doi: 10.1016/j.tim.2016.01.007. Epub 2016 Feb 6.
A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4(+) T cells in controlling viremia and preventing CMV-associated fetal disease.
缺乏关于母体免疫相关因素的知识,而这些因素对于保护胎盘和胎儿免受先天性巨细胞病毒(CMV)传播至关重要,这使得疫苗开发变得复杂。比亚拉斯及其同事的新研究表明,母体CD4(+) T细胞在控制病毒血症和预防CMV相关胎儿疾病方面起着关键作用。