• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Commentary: Age-related neurodegenerative disease research needs aging models.

作者信息

Wallace Lindsay M K, Howlett Susan E

机构信息

Department of Medicine, Dalhousie University Halifax, NS, Canada.

Department of Pharmacology, Dalhousie UniversityHalifax, NS, Canada; Institute of Cardiovascular Sciences, University of ManchesterManchester, UK.

出版信息

Front Aging Neurosci. 2016 Jan 29;8:9. doi: 10.3389/fnagi.2016.00009. eCollection 2016.

DOI:10.3389/fnagi.2016.00009
PMID:26858640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4731742/
Abstract
摘要

相似文献

1
Commentary: Age-related neurodegenerative disease research needs aging models.评论：与年龄相关的神经退行性疾病研究需要衰老模型。
Front Aging Neurosci. 2016 Jan 29;8:9. doi: 10.3389/fnagi.2016.00009. eCollection 2016.
2
Response: Commentary: Age-related neurodegenerative disease research needs aging models.回应：评论：与年龄相关的神经退行性疾病研究需要衰老模型。
Front Aging Neurosci. 2016 Mar 4;8:44. doi: 10.3389/fnagi.2016.00044. eCollection 2016.
3
Frailty and Neurodegenerative Disease: Anticipating the Future, Expanding the Framework.衰弱与神经退行性疾病：展望未来，拓展框架
J Frailty Aging. 2018;7(1):57-59. doi: 10.14283/jfa.2017.46.
4
Implementation of the mouse frailty index.小鼠衰弱指数的实施。
Can J Physiol Pharmacol. 2017 Oct;95(10):1149-1155. doi: 10.1139/cjpp-2017-0025. Epub 2017 May 2.
5
Assessment of Frailty in Animal Models.动物模型中的衰弱评估。
Interdiscip Top Gerontol Geriatr. 2015;41:15-25. doi: 10.1159/000381131. Epub 2015 Jul 17.
6
Frailty Assessment in Animal Models.动物模型中的虚弱评估。
Gerontology. 2019;65(6):610-619. doi: 10.1159/000501333. Epub 2019 Jul 22.
7
Fifteen years of progress in understanding frailty and health in aging.十五年来对衰老过程中脆弱性和健康的认识进展。
BMC Med. 2018 Nov 27;16(1):220. doi: 10.1186/s12916-018-1223-3.
8
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.迈向脆弱生物标志物：衰老和与年龄相关疾病中受调控的基因和途径的候选者。
Ageing Res Rev. 2018 Nov;47:214-277. doi: 10.1016/j.arr.2018.07.004. Epub 2018 Jul 30.
9
Advances in Preclinical Models of Frailty.衰弱临床前模型的进展
J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):867-869. doi: 10.1093/gerona/glx072.
10
On frail minds: addressing and assessing age-related neural decline and disease.论脆弱的心智：应对和评估与年龄相关的神经衰退及疾病
Eur J Ageing. 2018 Jun 13;16(2):205-213. doi: 10.1007/s10433-018-0481-4. eCollection 2019 Jun.

引用本文的文献

1
Changes in Metabolism and Proteostasis Drive Aging Phenotype in Sensory Neurons.新陈代谢和蛋白质稳态的变化驱动感觉神经元的衰老表型。
Front Aging Neurosci. 2020 Sep 15;12:573764. doi: 10.3389/fnagi.2020.573764. eCollection 2020.
2
Survival Curves and Behavioral Profiles of Female 3xTg-AD Mice Surviving to 18-Months of Age as Compared to Mice with Normal Aging.与正常衰老小鼠相比，存活至18月龄的雌性3xTg-AD小鼠的生存曲线和行为特征
J Alzheimers Dis Rep. 2017 Jul 6;1(1):47-57. doi: 10.3233/ADR-170011.
3
Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease.NF-κB的神经元基因靶点及其在阿尔茨海默病中的失调
Front Mol Neurosci. 2016 Nov 9;9:118. doi: 10.3389/fnmol.2016.00118. eCollection 2016.
4
Response: Commentary: Age-related neurodegenerative disease research needs aging models.回应：评论：与年龄相关的神经退行性疾病研究需要衰老模型。
Front Aging Neurosci. 2016 Mar 4;8:44. doi: 10.3389/fnagi.2016.00044. eCollection 2016.

本文引用的文献

1
Age-related neurodegenerative disease research needs aging models.与年龄相关的神经退行性疾病研究需要衰老模型。
Front Aging Neurosci. 2015 Sep 2;7:168. doi: 10.3389/fnagi.2015.00168. eCollection 2015.
2
Frailty: Scaling from Cellular Deficit Accumulation?衰弱：源自细胞缺陷积累的渐进过程？
Interdiscip Top Gerontol Geriatr. 2015;41:1-14. doi: 10.1159/000381127. Epub 2015 Jul 17.
3
Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.小鼠模型中多重用药导致的老年不良结局：衰老的影响
J Gerontol A Biol Sci Med Sci. 2016 May;71(5):571-7. doi: 10.1093/gerona/glv046. Epub 2015 May 4.
4
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.长寿干预对经过验证的小鼠临床衰弱指数的影响。
J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):333-9. doi: 10.1093/gerona/glu315. Epub 2015 Feb 22.
5
Reliability of a Frailty Index Based on the Clinical Assessment of Health Deficits in Male C57BL/6J Mice.基于雄性C57BL/6J小鼠健康缺陷临床评估的衰弱指数的可靠性
J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):686-93. doi: 10.1093/gerona/glu161. Epub 2014 Sep 9.
6
Policy: NIH to balance sex in cell and animal studies.政策：NIH 将在细胞和动物研究中平衡性别。
Nature. 2014 May 15;509(7500):282-3. doi: 10.1038/509282a.
7
Accumulation of non-traditional risk factors for coronary heart disease is associated with incident coronary heart disease hospitalization and death.冠心病非传统风险因素的积累与冠心病住院和死亡事件相关。
PLoS One. 2014 Mar 13;9(3):e90475. doi: 10.1371/journal.pone.0090475. eCollection 2014.
8
A clinical frailty index in aging mice: comparisons with frailty index data in humans.衰老小鼠的临床虚弱指数：与人类虚弱指数数据的比较。
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):621-32. doi: 10.1093/gerona/glt136. Epub 2013 Sep 19.
9
Assessing biological aging: the origin of deficit accumulation.评估生物老化：缺陷积累的起源。
Biogerontology. 2013 Dec;14(6):709-17. doi: 10.1007/s10522-013-9446-3. Epub 2013 Jul 17.
10
New horizons in frailty: ageing and the deficit-scaling problem.衰弱新视野：衰老与缺陷定标问题。
Age Ageing. 2013 Jul;42(4):416-23. doi: 10.1093/ageing/aft059. Epub 2013 Jun 5.