Vakharia Kunal, Siasios Ioannis, Dimopoulos Vassilios G, Pollina John
Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Neurosurgery, Kaleida Health, Buffalo, NY, USA.
J Clin Med Res. 2016 Mar;8(3):263-6. doi: 10.14740/jocmr2472w. Epub 2016 Jan 26.
Posterior reversible encephalopathy syndrome (PRES) usually manifests with severe headaches, seizures, and visual disturbances due to uncontrollable hypertension. A patient (age in the early 60s) with a history of renal cell cancer presented with lower-extremity weakness and paresthesias. Magnetic resonance imaging (MRI) of the thoracic spine revealed a T8 vertebral body metastatic lesion with cord compression at that level. The patient underwent preoperative embolization of the tumor followed by posterior resection and placement of percutaneous pedicle screws and rods. Postoperatively, the patient experienced decreased visual acuity bilaterally. Abnormal MRI findings consisted of T2 hyperintense lesions and fluid-attenuated inversion recovery changes in both occipital lobes, consistent with the unique brain imaging pattern associated with PRES. The patient's blood pressure was normal and stable from the first day of hospitalization. The patient was kept on high-dose steroid therapy, which was started intraoperatively, and improved within 48 hours after symptom onset.
后部可逆性脑病综合征(PRES)通常因难以控制的高血压而表现为严重头痛、癫痫发作和视觉障碍。一名有肾细胞癌病史的患者(60岁出头)出现下肢无力和感觉异常。胸椎磁共振成像(MRI)显示T8椎体转移性病变并伴有该水平的脊髓受压。患者接受了术前肿瘤栓塞,随后进行了后路切除并置入经皮椎弓根螺钉和棒。术后,患者双侧视力下降。MRI异常表现为双侧枕叶T2高信号病变和液体衰减反转恢复改变,符合与PRES相关的独特脑成像模式。患者自住院第一天起血压正常且稳定。患者持续接受术中开始的大剂量类固醇治疗,并在症状出现后48小时内病情好转。