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季节性温度变化不会影响心脏葡萄糖代谢。

Seasonal Temperature Changes Do Not Affect Cardiac Glucose Metabolism.

作者信息

Schildt Jukka, Loimaala Antti, Hippeläinen Eero, Nikkinen Päivi, Ahonen Aapo

机构信息

Department of Nuclear Medicine, HUS Medical Imaging Center, Helsinki University Central Hospital, Haartmaninkatu 4, 00029 Helsinki, Finland.

出版信息

Int J Mol Imaging. 2015;2015:916016. doi: 10.1155/2015/916016. Epub 2015 Dec 29.

DOI:10.1155/2015/916016
PMID:26858844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4709631/
Abstract

FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months. We obtained myocardial, liver, and mediastinal standardized uptake values (SUVs) as well as quantitative cardiac heterogeneity and the myocardial FDG uptake pattern. We also compared age and body mass index to other variables. The mean myocardial FDG uptake showed no significant difference between summer and winter months. Average outdoor temperature did not correlate significantly with myocardial SUVmax in either summer or winter. The heterogeneity of myocardial FDG uptake did not differ significantly between seasons. Outdoor temperature seems to have no significant effect on myocardial FDG uptake or heterogeneity. Therefore, warming the patients prior to attending cardiac PET studies in order to reduce physiological myocardial FDG uptake seems to be unnecessary.

摘要

氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)被广泛用于诊断心脏炎症,如心脏结节病。在评估心脏可能的病理性葡萄糖代谢时,生理性心肌氟代脱氧葡萄糖摄取常常会带来问题。诸如禁食、血糖和激素水平等多种因素会影响正常心肌葡萄糖代谢。此前尚未有关于室外温度对心肌氟代脱氧葡萄糖摄取影响的报道。我们回顾性分析了29例癌症患者,这些患者在温暖的夏季和寒冷的冬季分别接受了PET扫描。我们获取了心肌、肝脏和纵隔的标准化摄取值(SUV)以及定量心脏异质性和心肌氟代脱氧葡萄糖摄取模式。我们还将年龄和体重指数与其他变量进行了比较。夏季和冬季之间,平均心肌氟代脱氧葡萄糖摄取无显著差异。无论是夏季还是冬季,平均室外温度与心肌SUVmax均无显著相关性。不同季节之间,心肌氟代脱氧葡萄糖摄取的异质性无显著差异。室外温度似乎对心肌氟代脱氧葡萄糖摄取或异质性无显著影响。因此,为减少生理性心肌氟代脱氧葡萄糖摄取而在进行心脏PET检查前对患者进行保暖似乎并无必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/b2902c2fdae7/IJMI2015-916016.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/3b4bb7c0f2e3/IJMI2015-916016.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/9b1a4af5a3ea/IJMI2015-916016.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/58becde42d4d/IJMI2015-916016.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/a76d708ba5dd/IJMI2015-916016.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/b2902c2fdae7/IJMI2015-916016.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/3b4bb7c0f2e3/IJMI2015-916016.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/9b1a4af5a3ea/IJMI2015-916016.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/58becde42d4d/IJMI2015-916016.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/a76d708ba5dd/IJMI2015-916016.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f6/4709631/b2902c2fdae7/IJMI2015-916016.005.jpg

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本文引用的文献

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Clin Radiol. 2013 Jan;68(1):e59-71. doi: 10.1016/j.crad.2012.09.007. Epub 2012 Nov 22.
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Heterogeneous myocardial FDG uptake and the disease activity in cardiac sarcoidosis.心肌 FDG 摄取的异质性与心脏结节病的疾病活动。
JACC Cardiovasc Imaging. 2010 Dec;3(12):1219-28. doi: 10.1016/j.jcmg.2010.09.015.
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Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans.户外温度、年龄、性别、体重指数和糖尿病状态决定了 18F-FDG 检测到的人类 BAT 的患病率、质量和葡萄糖摄取活性。
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Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas).用15O标记水PET进行心肌灌注定量分析:新型心脏分析软件(Carimas)具有高重现性。
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