Effect of blood glucose level on standardized uptake value (SUV) in F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements.

OBJECTIVES

To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in F-FDG-PET scan.

METHODS

A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUV and SUV adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, F-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUV or SUV among five different BGL groups (< 110, 110-125, 125-150, 150-200, and > 200 mg/dl).

RESULTS

Individual data for a total of 20,807 SUV and SUV measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUV and SUV in brain (p < 0.001, p < 0.001,) and muscle (p < 0.001, p < 0.001) and increased SUV and SUV in liver (p = 0.001, p = 0004) and blood pool (p = 0.008, p < 0.001). No significant correlation was found between BGL and SUV or SUV in tumors. In the ANOVA test, all hyperglycemic groups had significantly lower SUVs compared with the euglycemic group in brain and muscle, and significantly higher SUVs in liver and blood pool. However, in tumors only the hyperglycemic group with BGL of > 200 mg/dl had significantly lower SUV.

CONCLUSION

If BGL is lower than 200 mg/dl no interventions are needed for lowering BGL, unless the liver is the organ of interest. Future studies are needed to evaluate sensitivity and specificity of FDG-PET scan in diagnosis of malignant lesions in hyperglycemia.